Stress granules in colorectal cancer:Current knowledge and potential therapeutic applications  

作　　者：Noémie Legrand Dan A Dixon Cyril Sobolewski 

机构地区：[1]Department of Medicine,Faculty of Medicine,University of Geneva,Geneva CH-1211,Switzerland [2]Department of Molecular Biosciences,University of Kansas,Lawrence,Kansas,and University of Kansas Cancer Center,Lawrence,KS 66045,United States [3]Department of Cell Physiology and Metabolism,Faculty of Medicine,University of Geneva,Geneva CH-1211,Switzerland

出　　处：《World Journal of Gastroenterology》2020年第35期5223-5247,共25页世界胃肠病学杂志（英文版）

基　　金：Supported by Geneva Cancer League,No.1711;National Institutes of Health,No.R01 CA243445;and National Cancer Institute Cancer Center Support Grant,No.P30 CA168524.

摘　　要：Stress granules(SGs)represent important non-membrane cytoplasmic compartments,involved in cellular adaptation to various stressful conditions(e.g.,hypoxia,nutrient deprivation,oxidative stress).These granules contain several scaffold proteins and RNA-binding proteins,which bind to mRNAs and keep them translationally silent while protecting them from harmful conditions.Although the role of SGs in cancer development is still poorly known and vary between cancer types,increasing evidence indicate that the expression and/or the activity of several key SGs components are deregulated in colorectal tumors but also in pre-neoplastic conditions(e.g.,inflammatory bowel disease),thus suggesting a potential role in the onset of colorectal cancer(CRC).It is therefore believed that SGs formation importantly contributes to various steps of colorectal tumorigenesis but also in chemoresistance.As CRC is the third most frequent cancer and one of the leading causes of cancer mortality worldwide,development of new therapeutic targets is needed to offset the development of chemoresistance and formation of metastasis.Abolishing SGs assembly may therefore represent an appealing therapeutic strategy to re-sensitize colon cancer cells to anti-cancer chemotherapies.In this review,we summarize the current knowledge on SGs in colorectal cancer and the potential therapeutic strategies that could be employed to target them.

关 键 词：Stress-Granules Colorectal cancer Adenylate-Uridylate-rich element-binding proteins Post-transcriptional regulation ONCOGENES Tumor suppressors 

分 类 号：R735.34[医药卫生—肿瘤]