New approach of medicinal herbs and sulfasalazine mixture on ulcerative colitis induced by dextran sodium sulfate  

作　　者：Mi-Rae Shin Hae-Jin Park Bu-Il Seo Seong-Soo Roh 

机构地区：[1]Department of Herbology,Korean Medicine College,Daegu Haany University,Suseong-gu,Deagu 42158,South Korea [2]DHU Bio Convergence Testing Center,Gyeongsan-si,Gyeongsangbuk-do 38610,South Korea

出　　处：《World Journal of Gastroenterology》2020年第35期5272-5286,共15页世界胃肠病学杂志（英文版）

基　　金：Traditional Korean Medicine R&D Program funded by the Ministry of Health&Welfare through the Korea Health Industry Development Institute(KHIDI),No.HI15C00255;and National Research Foundation of Korea(NRF)funded by the Korean government(MSIP),No.2018R1A5A2025272.

摘　　要：BACKGROUND Sulfasalazine has been used as a standard-of-care in ulcerative colitis for decades,however,it results in severe adverse symptoms,such as hepatotoxicity,blood disorders,male infertility,and hypospermia.Accordingly,the new treatment strategy has to enhance pharmacological efficacy and stimultaneously minimize side effects.AIM To compare the anti-inflammatory action of sulfasalazine alone or in combination with herbal medicine for ulcerative colitis in a dextran sodium sulfate(DSS)-induced colitis mouse model.METHODS To induce ulcerative colitis,mice received 5%DSS in drinking water for 7 d.Animals were divided into five groups(n=9 each)for use as normal(non-DSS),DSS controls,DSS+sulfasalazine(30 mg/kg)-treatment experimentals,DSS+sulfasalazine(60 mg/kg)-treatment experimentals,DSS+sulfasalazine(30 mg/kg)+Citrus unshiu peel and Bupleuri radix mixture(30 mg/kg)(SCPB)-treatment experimentals.RESULTS The SCPB treatment showed an outstanding effectiveness in counteracting the ulcerative colitis,as evidenced by reduction in body weight,improvement in crypt morphology,increase in antioxidant defenses,down-regulation of proinflammatory proteins and cytokines,and inhibition of proteins related to apoptosis.CONCLUSIONSCPB may represent a promising alternative therapeutic against ulcerative colitis,without inducing adverse effects.

关 键 词：Dextran sulfate sodium Ulcerative colitis ANTI-INFLAMMATORY SULFASALAZINE Citrus unshiu peel and Bupleuri radix mixture Apoptosis 

分 类 号：R574.62[医药卫生—消化系统]