球周注射凝胶聚合物加固手术对青少年变性近视的疗效  

The efficacy of sclera-fortifying injection with collagen polymer for degenerative myopia in the adolescents

作　　者：王媛 朱冬梅 李秀娟[2] 张金嵩[2] Wang Yuan;Zhu Dongmei;Li Xiujuan;Zhang Jinsong(Department of Ophthalmology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450007,China;Department of Ophthalmology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学附属郑州中心医院眼科,郑州450007 [2]郑州大学第一附属医院眼科,郑州450052

出　　处：《中华眼外伤职业眼病杂志》2020年第9期649-654,共6页Chinese Journal of Ocular Trauma and Occupational Eye Disease

基　　金：河南省自然科学基金(182300410339);河南省高等学校重点科研项目(19A320076);河南省医学科技攻关计划联合共建项目(2018020799);河南省医学科技攻关计划联合共建项目(2018020785)。

摘　　要：目的评价球周注射凝胶聚合物加固手术对青少年变性近视的临床疗效.方法前瞻性病例对照研究.收集2014年5月至2016年5月青少年变性近视41例(41只眼),随机分为临床试验组20例(20只眼),行球周注射凝胶聚合物加固手术;对照组,21例(21只眼)验配框架眼镜,术后随访12个月,观察两组治疗效果.结果术后1个月和3个月:试验组的裸眼视力(logMAR)为0.44±0.16和0.45±0.17;最佳矫正视力(logMAR)为0.09±0.07和0.11±0.09,均优于对照组的0.86±0.20、0.89±0.19,0.27±0.20、0.32±0.21;试验组眼轴长度为(26.05±1.19)mm和(26.19±1.18)mm,屈光度为(8.04±2.04)D和(8.07±2.23)D,对照组眼轴长度和屈光度分别为(27.77±1.28)mm、(27.92±1.26)mm,(8.60±2.29)D、(8.63±2.31)D,试验组均低于对照组(P<0.05).术后6个月试验组和对照组的裸眼视力分别为0.47±0.17和0.91±0.21,最佳矫正视力分别为0.15±0.11和0.36±0.24,眼轴长度(26.38±1.33)mm,(28.12±1.25)mm,两组间差异有统计学意义(P<0.05),而两组间屈光度差异无统计学差异(P>0.05),术后12个月两组间各观察指标差异均无统计学意义(P>0.05).结论球周注射凝胶聚合物加固手术治疗青少年变性近视的短期效果良好,但其远期疗效及是否需反复注射等问题有待研究.Objective To evaluate the efficacy of sclera-fortifying injection with collagen polymer for degenerative myopia in the adolescents.Methods In this prospective case-control study,a total of 41 eyes of 41 teenagers with degenerative myopia in the First Affiliated Hospital of Zhengzhou University from May 2014 to May 2016 were collected.All cases were randomly divided into two groups.In the clinical trial group,20 eyes of 20 cases were treated with sclera-fortifying injection with collagen polymer.And in the control group,frame glasses were used on 21 eyes of 21 cases.The follow-up time was 1,3,6,and 12 months.The efficacy of the two groups were observed.Results At 1 and 3 months after surgery,the UCVA(logMAR)of the trial group were 0.44±0.16,0.45±0.17,and the BCVA(logMAR)were 0.09±0.07,0.11±0.09,respectively.UCVA and BCVA in the control group were 0.86±0.20,0.89±0.19,and 0.27±0.20,0.32±0.21,respectively.The ocular axis and the diopter at 1 and 3 months after surgery were(26.05±1.19)mm,(26.19±1.18)mm,(8.04±2.04)D,(8.07±2.23)D in the trial group and(27.77±1.28)mm,(27.92±1.26)mm,(8.60±2.29)D,(8.63±2.31)D in the control group.The differences were statistically significant between the two groups(P<0.05).The UCVA at 6 months postoperatively was 0.47±0.17 in the trial group and 0.91±0.21 in the control group.The BCVA was 0.15±0.11 and 0.36±0.24 and the ocular axis was(26.38±1.33)mm,(28.12±1.25)mm.The differences were statistically significant between the two groups(P<0.05).However there was no statistical difference in refractive error between the two groups(P>0.05),and there was no statistical significance in observed indexes at 12 months after injection(P>0.05).Conclusion Sclera-fortifying injection with collagen polymer is effective for degenerative myopia in the adolescents.However,long-term effects after sclera-fortifying injection and the necessity of repeat injection are undefined.

关 键 词：近视 变性 青少年 注射 球周 凝胶聚合物 

分 类 号：R779.6[医药卫生—眼科]