采血时间对低出生体重新生儿CAH筛查中17-OHP水平的影响分析  

An Analysis the Effects of Sampling Age Time on the 17-Hydroxyprogesterone Level of Low Birth Weight Neonates in CAH Newborn Screening

作　　者：万智慧[1] 于璐[1] 简永建 李艳霞[1] 刘伟[1] 马志军[1] WAN Zhihui;YU Lu;JIAN Yongjian;LI Yanxia;LIU Wei;MA Zhijun(Department of Clinical Laboratory,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing Maternal and Child Health Care Hospital,Beijing 100026,China)

机构地区：[1]首都医科大学附属北京妇产医院北京妇幼保健院检验科,北京100026

出　　处：《标记免疫分析与临床》2020年第9期1457-1459,1565,共4页Labeled Immunoassays and Clinical Medicine

基　　金：首都医科大学基础-临床科研合作基金(编号:17JL58)。

摘　　要：目的分析采血时间对低体重新生儿先天性肾上腺皮质增生症(congenital adrenal hyperplasia,CAH)筛查中17羟孕酮(17-OH-progesterone,17-OHP)水平的影响。方法回顾性分析北京市新生儿疾病筛查中心2019年1月至2019年8月筛查的低体重新生儿样本共6891例,采用时间分辨荧光免疫分析方法检测新生儿干血滤纸片中17-OHP的水平,按照体重和采血时间进行分组统计分析。结果新生儿出生体重越低,采血时间越长;低体重新生儿采血时间越长,17-OHP的水平越低。结论采血时间对低体重新生儿CAH筛查中17-OHP水平有显著影响,在对低体重新生儿的CAH筛查结果进行判定时还应充分考虑采血时间的影响。Objective To analyze the effects of sampling age time on the 17-hydroxyprogesterone(17-OHP)levels among low birth weight neonates in CAH newborn screening.Methods The 17-OHP concentrations in dried blood spots were measured by time-resolved immunofluorescence and were grouped in terms of birth weight(BW)and sampling age time among 6891 low birth weight newborns.Results Significant differences in 17-OHP concentrations were observed among low birth weight newborns with different sampling age,in which the 17-OHP level decreased while the sampling time increased.Also,the sampling age increased while the birth weight decreased.Conclusion Sampling age time has significant effects on the concentration of 17-OHP in low birth weight neonates.

关 键 词：采血时间 体重 17羟孕酮 新生儿疾病筛查 先天性肾上腺皮质增生症 

分 类 号：R722.11[医药卫生—儿科]