以SARS-CoV-2为中心的PBL方案在线上生物化学教学中的应用  

The application of SARS-CoV-2 centered PBL program in the online education of Biochemistry

作　　者：丁智[1] 杨荣武[1] DING Zhi;YANG Rongwu(School of Life Sciences,Nanjing University,Nanjing 210023,China)

机构地区：[1]南京大学生命科学学院,南京210023

出　　处：《生命的化学》2020年第8期1413-1418,共6页Chemistry of Life

基　　金：2019年度南京大学“千”层次优质课程建设项目;2017年度南京大学“百”层次优质课程建设项目。

摘　　要："生物化学"在生命科学教育中处于基础和核心的位置,教学的信息量大、难度高。教师们一直在努力探讨和提高"生物化学"的教学效果。目前,在疫情影响下,理论课程转入线上教学,对这门课程的教学带来了新的挑战和契机。生物化学的本质是在分子层面上描述生命活动,因此,我们选用SARS-CoV-2这一相对简单的生命形式为线索,按照"结构生物化学"的教学进展,从蛋白质、核酸到酶、受体再到疫苗和药物发展步步推进,设计并践行了五步走的PBL(practice-based learning)的教学方案,并把教学的效果分享出来,与教学同行一起探讨和提高。Biochemistry is at the very center of life science education.This paper tried to explore new strategies to improve teaching effects due to the vast and fast-growing knowledge.At present,under the influence of the pandemic,the curriculum has been transferred to online form.It brings new challenges and opportunities.The essence of Biochemistry is to describe life activities at the molecular level,therefore,we choose the SARSCoV-2 virus,a relatively simple form of life,as a thread.In accordance with the advances in the course of Structural Biochemistry,a five-step practice-based learning program including protein,nucleic acid,enzymes,receptors,vaccine and medicine development was designed and carried out step by step.Here we share the detailed process of the program to refine and improve it.

关 键 词：结构生物化学 PBL SARS-CoV-2 线上教学 

分 类 号：Q5-4[生物学—生物化学] G434[文化科学—教育学]