Runx2基因表达与正畸牙移动牙周改建  

Expression of Runx2 gene and periodontal reconstruction in orthodontic tooth movement

作　　者：邵佳琪 张佳男 卢海平[1] SHAO Jiaqi;ZHANG Jianan;LU Haiping(School of Stomatology,Zhejiang Chinese Medical University,Hangzhou 310000,China)

机构地区：[1]浙江中医药大学口腔医学院,浙江杭州310000 [2]浙江大学医学院附属邵逸夫医院牙科正畸中心,浙江杭州310000

出　　处：《口腔医学》2020年第9期851-854,共4页Stomatology

基　　金：浙江省自然基金(LY19H140001)

摘　　要：Runx2是一种成骨分化特异性转录因子,在成骨细胞的形成以及分化、破骨细胞的形成和活化等过程中都发挥着重要的作用。正畸牙移动(orthodontic tooth movement,OTM)是牙齿在受到一定正畸力的作用后,对牙周膜产生压缩或牵张的力,牙周组织发生生理限度内的改建,继而达到牙齿移动的一个过程。不少学者对加速正畸牙移动和维持正畸牙移动效果的方法感兴趣,研究认为Runx2在正畸牙移动过程中牙周改建有重要作用,其基因的表达高低在正畸牙移动牙周改建具有一定的积极作用,本文对该方面相关研究结果进行一个阐述。Runx2 is a specific transcription factor of osteogenic differentiation,which plays an important role in the formation and differentiation of osteoblasts,the formation and activation of osteoclasts.Orthodontic tooth movement(OTM)is a process in which teeth compress or stretch the periodontal ligament after being subjected to a certain orthodontic force,and the periodontal tissue is rebuilt within the physiological limit,leading to the tooth movement.Many scholars are interested in the methods of accelerating orthodontic tooth movement and maintaining orthodontic tooth movement effect.It is considered that Runx2 plays an important role in periodontal remodeling during orthodontic tooth movement,whose gene expression plays a positive role in periodontal reconstruction in orthodontic tooth movement.In this paper,the related research results are described.

关 键 词：RUNX2 牙移动 正畸力 成骨细胞 

分 类 号：R783.5[医药卫生—口腔医学]