双胎妊娠羊膜腔穿刺23例分析  

Clinical analysis of 23 cases of twin pregnancy with amniocentesis

作　　者：黄婷婷[1] 刘艳秋[1] 刘丹平[1] 周吉会[1] HUANG Tingting;LIU Yanqiu;LIU Danping(Jiangxi Maternal and Child Health Care Hospital,Nanchang 330006,China)

机构地区：[1]江西省妇幼保健院产前诊断中心,南昌330006

出　　处：《江西医药》2020年第10期1363-1365,1382,共4页Jiangxi Medical Journal

基　　金：江西省卫生健康委科技计划项目,编号20191102。

摘　　要：目的探讨双胎妊娠羊膜腔穿刺术的临床应用价值。方法回顾性分析在我院产前诊断中心行羊膜腔穿刺术的23例双胎妊娠孕妇(45个胎儿),分析其染色体核型及染色体微阵列检测结果及后续处理。结果共45个胎儿进行产前诊断,标本行染色体核型分析及微阵列分析,核型分析提示1例18三体,2例21三体,微阵列分析检出4例致病性变异,致病性染色体异常检出率15.56%(7/45),术后2周随访均未发生流产等并发症,6例孕妇实施了选择性减胎术。结论双胎羊膜腔穿刺术是发现双胎妊娠胎儿染色体及遗传基因是否正常的有效手段,为双胎孕妇是否需要行孕期选择性减胎术提供临床依据。Objective To investigate the clinical value of amniocentesis in twin pregnancy.Methods The 23 pregnant women(45 fetuses)with twin pregnancy who underwent amniocentesis in the prenatal diagnosis center of our hospital were analyzed retrospectively.Results A total of 45 fetuses were diagnosed,7 fetuses had chromosome abnormality(15.56%,7/45),and no complications such as abortion occurred in 2 weeks follow-up.6 pregnant women underwent selective fetal reduction.Conclusion Amniocentesis is an effective method to find out whether the chromosome and genetic gene of twin pregnancy fetus are normal,which provides the clinical basis for the selective reduction of twin pregnancy.

关 键 词：羊膜腔穿刺 双胎妊娠 产前诊断 

分 类 号：R714.5[医药卫生—妇产科学]