Emerging relationship between RNA helicases and autophagy  

RNA解旋酶和自噬之间的新关系

作　　者：Miao-miao ZHAO Ru-sha WANG Yan-lin ZHOU Zheng-gang YANG 

机构地区：[1]The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,the First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China [2]Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,Hangzhou 310003,China [3]Department of Gastroenterology,the First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310006,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2020年第10期767-778,共12页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：State S&T Project of 13th Five Year of China(No.2018ZX10302206);the National Basic Research Program(973)of China(No.2017YFA0503402);the Independent Project Fund of the State Key Laboratory for Diagnosis and Treatment of Infectious Disease,Hangzhou,China。

摘　　要：RNA helicases,the largest family of proteins that participate in RNA metabolism,stabilize the intracellular environment through various processes,such as translation and pre-RNA splicing.These proteins are also involved in some diseases,such as cancers and viral diseases.Autophagy,a self-digestive and cytoprotective trafficking process in which superfluous organelles and cellular garbage are degraded to stabilize the internal environment or maintain basic cellular survival,is associated with human diseases.Interestingly,similar to autophagy,RNA helicases play important roles in maintaining cellular homeostasis and are related to many types of diseases.According to recent studies,RNA helicases are closely related to autophagy,participate in regulating autophagy,or serve as a bridge between autophagy and other cellular activities that widely regulate some pathophysiological processes or the development and progress!on of diseases.Here,we summarize the most recent studies to understand how RNA helicases function as regulatory proteins and determine their association with autophagy in various diseases.RNA解旋酶是参与RNA代谢的最大的蛋白质家族,通过翻译和前体RNA剪接等各种过程来稳定细胞内环境。这些蛋白质还与一些疾病有关,如癌症和病毒性疾病。自噬是一种口我消化和保护细胞的运输过程,通过降解多余的细胞器和细胞垃圾来稳定内部环境或维持细胞的基本生存,与人类疾病有关。与自噬相似,RNA解旋酶在维持细胞内稳态中发挥着重要的作用,与多种疾病相关。近年来的研究表明,RNA解旋酶与自噬密切相关,参与调节自噬或作为自噬与其他细胞活动之间的桥梁,广泛影响了一些病理生理过程。本文总结了最新的研究,以了解RNA解旋酶调节自噬的机制以及这些机制与疾病之间的联系。

关 键 词：RNA helicase AUTOPHAGY HOMEOSTASIS REGULATION 

分 类 号：R341[医药卫生—基础医学]