Joint Multi-modal Parcellation of the Human Striatum:Functions and Clinical Relevance  

作　　者：Xiaojin Liu Simon B.Eickhoff Felix Hoffstaedter Sarah Genon Svenja Caspers Kathrin Reetz Imis Dogan Claudia R.Eickhoff Ji Chen Julian Caspers Niels Reuter Christian Mathys Andre Aleman Renaud Jardri Valentin Riedl Iris E.Sommer Kaustubh R.Patil 

机构地区：[1]Institute of Neuroscience and Medicine(INM-7,Brain and Behaviour),Research Centre Jiilich,Jiilich,Germany [2]Institute of Systems Neuroscience,Heinrich Heine University Dusseldorf,Dusseldorf,Germany [3]Institute of Neuroscience and Medicine(INM-1),Research Centre Jiilich,52428 Jiilich,Germany [4]Institute for Anatomy I,Medical Faculty,Heinrich Heine University Dusseldorf,40225 Dusseldorf,Germany [5]Jiilich Aachen Research Alliance-BRAIN(JARA)Institute of Molecular Neuroscience and Neuroimaging,Forschungszentrum Jiilich,Rheinisch Westfallische Technische Hochschule(RWTH)Aachen University,52074 Aachen,Germany [6]Department of Neurology,Rheinisch Westfallische Technische Hochschule(RWTH)Aachen University,52074 Aachen,Germany [7]Institute of Clinical Neuroscience and Medical Psychology,Medical Faculty,University of Dusseldorf,40225 Dusseldorf,Germany [8]Department of Diagnostic and Interventional Radiology,Medical Faculty,University of Dusseldorf,40225 Dusseldorf,Germany [9]Institute of Radiology and Neuroradiology,Evangelisches Krankenhaus,University of Oldenburg,26129 Oldenburg,Germany [10]Department of Neuroscience,University Medical Center Groningen,University of Groningen,9713 AV Groningen,The Netherlands [11]SCALab(CNRS UMR9193)&CHU de LiUe,Hopital Fontan,Pole de Psychiatrie(CURE),Universite de Lille,59037 Lille,France [12]Departments of Neuroradiology,Nuclear Medicine and Neuroimaging Center,Technische Universitat Miinchen,80333 Munich,Germany

出　　处：《Neuroscience Bulletin》2020年第10期1123-1136,共14页神经科学通报（英文版）

基　　金：This work was supported by the Deutsche Forschungsgemeinschaft(GE 2835/1-1,El 816/4-1);the Helmholtz Portfolio Theme 4 Supercomputing and Modelling for the Human Brain'and the European Union's Horizon 2020 Research and Innovation Programme under Grant Agreement No.785907(HBP SGA2);We gratefully acknowledge financial support from the China Scholarship Council(201606750003).

摘　　要：The human striatum is essential for both lowand high-level functions and has been implicated in the pathophysiology of various prevalent disorders,including Parkinson's disease(PD)and schizophrenia(SCZ).It is known to consist of structurally and functionally divergent subdivisions.However,previous parcellations are based on a single neuroimaging modality,leaving the extent of the multi-modal organization of the striatum unknown.Here,we investigated the organization of the striatum across three modalities—resting-state functional connectivity,probabilistic diffusion tractography,and structural covariance—to provide a holistic convergent view of its structure and function.We found convergent clusters in the dorsal,dorsolateral,rostral,ventral,and caudal striatum.Functional characterization revealed the anterior striatum to be mainly associated with cognitive and emotional functions,while the caudal striatum was related to action execution.Interestingly,significant structural atrophy in the rostral and ventral striatum was common to both PD and SCZ,but atrophy in the dorsolateral striatum was specifically attributable to PD.Our study revealed a cross-modal convergent organization of the striatum,representing a fundamental topographical model that can be useful for investigating structural and functional variability in aging and in clinical conditions.

关 键 词：STRIATUM MULTI-MODAL Connectivity-based parcellation Convergent clusters Voxel-based morphometry Parkinson's disease SCHIZOPHRENIA 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R749.3[医药卫生—临床医学]