Analysis of related factors of optical quality in healthy Chinese adults:a community-based population study  

作　　者：Xi-Fang Zhang Li-Ya Qiao Xiao-Gu Cai Xiao-Xia Li Jia-Xuan Tan Zheng Guan Ye Zhang Kai Cao Ning-Li Wang 

机构地区：[1]Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Institute of Ophthalmology,Beijing Ophthalmology and Visual Sciences Key Laboratory,Beijing 100730,China.

出　　处：《Chinese Medical Journal》2020年第19期2308-2314,共7页中华医学杂志（英文版）

基　　金：a research special fund of the Ministry of Health of the People’s Republic of China(No.201002019).

摘　　要：Background:In recent years,visual quality has been extensively investigated in various conditions.In this community-based population study,we analyzed the effects of aging,refraction,and Lens Opacification Classification System III(LOCSIII)score on retinal imaging quality in healthy Chinese adults.Methods:This cross-sectional study was conducted on sub-group subjects from The Handan Eye Study between October 2012 and January 2013.Healthy subjects over 30-years-old with logarithm of the minimal angle of resolution(logMAR)best-corrected visual acuity(BCVA)less than 0 were included.Retinal image quality was measured by optical quality analysis system(OQAS)and recorded as modulation transfer function cutoff frequency(MTFcutoff),OQAS value(OV)100%,OV20%,OV9%,Strehl ratio(SR),and objective scatter index(OSI).The correlation between age,spherical equivalent refraction(SE),LOCSIII score,and optical quality parameters were investigated by multivariate analysis.Results:Among 1108 verified subjects,690 subjects(1380 eyes)met the inclusion criteria.Their age ranged from 30 to 76 years,SE ranged from-4.75 to 2.75 D.They were divided into five age groups(30–39,40–49,50–59,60–69,and≥70 years)for further analysis.After multivariate analysis by mixed-effect linear model,SR(t=-3.03,P=0.002),OV20%(t=-2.39,P=0.017),and OV9%(t=-3.16,P=0.001)significantly decreased with the increasing age,whereas logMAR BCVA(t=4.42,P<0.001)and OSI(t=4.46,P<0.001)significantly increased with age.As SE increased,SR(t=2.74,P=0.01),OV20%(t=2.31,P=0.02),and OV9%(t=2.79,P=0.005)significantly elevated,and OSI(t=-3.38,P<0.001)significantly decreased.With the increase in cortical opacity score,all optical quality parameters except for SR significantly decreased,including MTFcutoff(t=-2.78,P=0.01),OV100%(t=-2.78,P=0.005),OV20%(t=-2.60,P=0.009),and OV9%(t=-2.05,P=0.04).As posterior sub capsular opacity score increased,MTFcutoff(t=-2.40,P=0.02)and OV100%(t=-2.40,P=0.01)significantly decreased,while OSI(t=7.56,P<0.001)significantly increased.Conclusions:

关 键 词：Cross-sectional study Prospective study VISION AGING Refractive errors CATARACT 

分 类 号：R774.1[医药卫生—眼科]