Microalgae-enabled photosynthetic alleviation of tumor hypoxia for enhanced nanotherapies  

基于微藻的光合作用改善肿瘤乏氧以提高纳米治疗效果

作　　者：Hui Hu Xiaoqin Qian Yu Chen 胡慧;钱晓芹;陈雨(Medmaterial Research Center,Jiangsu University Affiliated People’s Hospital,Zhenjiang 212002,China;School of Life Sciences,Shanghai University,Shanghai 2000444,China;State Key Lab of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,China)

机构地区：[1]Medmaterial Research Center,Jiangsu University Affiliated People’s Hospital,Zhenjiang 212002,China [2]School of Life Sciences,Shanghai University,Shanghai 2000444,China [3]State Key Lab of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,China

出　　处：《Science Bulletin》2020年第22期1869-1871,M0003,共4页科学通报（英文版）

基　　金：National Key R&D Program of China(2016YFA0203700);the National Natural Science Foundation of China(51672303,81971629,and 81771848);Excellent Young Scientist Foundation of National Natural Science Foundation of China(51722211);Shanghai Sailing Program(81901752);Program of Shanghai Subject Chief Scientist(18XD1404300)。

摘　　要：Hypoxia is a common feature of the most solid tumors attributing to the rapid growth and abnormal proliferation of the vascular system[1],which unfortunately causes the resistance of tumor cells to oxygen-dependent cancer-therapeutic modalities,such as the well-known and well-demonstrated radiotherapy(RT)and photodynamic therapy(PDT)[2].In particular,the therapeutic efficacy of PDT has been substantially restricted by hypoxia based on the limited conversion of oxygen(O2)to reactive oxygen species(ROS)that usually deteriorates the degree of hypoxia in turn.

关 键 词：肿瘤乏氧 THERAPEUTIC MODALITIES 

分 类 号：R730.5[医药卫生—肿瘤]