SNAP25MnlI多态性与儿童注意缺陷多动障碍关联性的meta分析  

A meta-analysis of association between SNAP25MnlI polymorphisms and attention-deficit/hyperactivity disorder in children

作　　者：杨玥 苏琪茹 杨斌让 YANG Yue;SU Qiru;YANG Binrang(Zhuhai Campus of Zunyi Medical University,Zhuhai 519041,Guangdong Province,China;Shenzhen Children's Hospital,Shenzhen 518038,Guangdong Province,China)

机构地区：[1]遵义医科大学珠海校区,广东珠海519041 [2]深圳市儿童医院,广东深圳518038

出　　处：《中国心理卫生杂志》2020年第12期1022-1028,共7页Chinese Mental Health Journal

基　　金：国家自然科学基金(81271512);深圳市医疗卫生三名程项目(SZSM201612036)。

摘　　要：目的:评价突触相关蛋白25基因(SNAP25)MnlI多态性与儿童注意缺陷多动障碍(ADHD)的关联性。方法:检索Pubmed、Embase、Web of Science、Google Scholar、中国知网、维普全文电子期刊、万方数据库和中国生物医学文献数据库,检索时限均为自建库至2019年11月,搜集SNAP25MnlI多态性与ADHD相关的研究。结果:本研究包含7项病例对照研究和8项传递不平衡检验。Meta分析显示,存在中度异质性(I^2=45.6%),因此采用随机效应模型分析,结果支持SNAP25MnlI多态性与儿童ADHD存在关联[OR(95%CI)=1.16(1.03~1.30),P<0.05]。按人种及研究类型进行亚组分析后,得到在白种人、病例对照研究中SNAP25MnlI多态性与儿童ADHD风险存在关联[OR(95%CI)=1.10(1.00~1.22)、1.38(1.11~1.70),均P<0.05]。结论:本研究提示在白种人中或采用病例对照研究的实验方法表明SNAP25MnlI多态性可能会增加儿童ADHD的风险。Objective:To evaluate the association of synaptosomal-associated protein 25 gene MnlI polymorphism and attention-deficit/hyperactive disorder in children.Methods:Pubmed,Embase,Web of Science,Google Scholar,CNKI,VIP,Wangfang Data and CBM were searched from inception to November 2019 to collect studies about SNAP25MnlI polymorphism and ADHD.Results:Seven case-control studies and eight transmission disequilibrium tests were included in this meta-analysis.The overall meta-analysis showed heterogeneity(I^2=45.6%),so the random effects model was used and showed significant association between SNAP25 MnlI polymorphism and ADHD risk in children [OR(95% CI)=1.16(1.03-1.30),P<0.05].Stratified analyses showed that significant associations were found in Caucasian and case-control study,the OR and 95% CI respectively were [OR(95% CI)=1.10(1.00-1.22),1.38(1.11-1.70),(Ps<0.05)].Funnel plots showed that there was no publication bias in the included literature.Conclusion:This study suggests that in Caucasian or case-control studies,SNAP25MnlI polymorphisms may contribute to the risk of ADHD in children.

关 键 词：突触相关蛋白25基因 注意缺陷多动障碍 病例对照研究 传递不平衡检验 META分析 

分 类 号：R749.94[医药卫生—神经病学与精神病学]