Schwann-like adipose-derived stem cells as a promising therapeutic tool for peripheral nerve regeneration:effects of cholinergic stimulation  

作　　者：Roberta Piovesana Alessandro Faroni Ada Maria Tata Adam J.Reid 

机构地区：[1]Department of Biology and Biotechnologies“Charles Darwin”,Sapienza,University of Rome,Rome,Italy [2]Blond McIndoe Laboratories,Division of Cell Matrix Biology and Regenerative Medicine,School of Biological Sciences,Faculty of Biology,Medicine and Health,The University of Manchester,Manchester Academic Health Science Centre,Manchester,UK [3]Research Centre of Neurobiology“Daniel Bovet”,Sapienza,University of Rome,Rome,Italy [4]Department of Plastic Surgery&Burns,Wythenshawe Hospital,Manchester University NHS Foundation Trust,Manchester Academic Health Science Centre,Manchester,UK

出　　处：《Neural Regeneration Research》2021年第6期1218-1220,共3页中国神经再生研究（英文版）

基　　金：supported by Ateneo Sapienza Funds 2017(RM11715C7F959CA4);“Avvio Giovani”Project 2018(AR11816435A0F81D)from Ateneo Sapienza to RP.RP fellowship was also supported by CIB 2018;AF and AJR are supported by the Hargreaves and Ball Trust,the Academy of Medical Sciences(AMS-SGCL7);by Seed Corn Funding from the Rosetrees Trust and the Stoneygate Trust(M746).

摘　　要：Schwann-like adipose-derived stem cells and nerve injury:Peripheral nerve injuries(PNIs)are a common clinical problem usually as a consequence of trauma.Despite optimal surgical management,PNI has a lifelong impact on function and wellbeing of the patient.The peripheral nervous system(PNS)has regenerative capability,in contrast to the central nervous system(CNS),and is dependent on the plasticity of the peripheral glia,Schwann cells(SCs).Despite this regenerative capability,PNI recovery of sensorial and motor function is always incomplete causing pain,cold intolerance,paralysis and impairment of activities of daily living.

关 键 词：STIMULATION INJURIES PARALYSIS 

分 类 号：R745[医药卫生—神经病学与精神病学]