新型异斯特维醇吲哚衍生物的合成  

Synthesis of Novel Isosteviol-Indole Derivatives

作　　者：刘从军 韦畅勇 赵国欣 王宇飞 陶京朝[2] LIU Cong-jun;WEI Chang-yong;ZHAO Guo-xin;WANG Yu-fei;TAO Jing-chao(Department of Chemical Engineering and Food Science,Zhengzhou Institute of Technology,Zhengzhou,450044,China;College of Chemistry and Molecular Engineering,Zhengzhou University,Zhengzhou,450001,China)

机构地区：[1]郑州工程技术学院化工食品学院,河南郑州450044 [2]郑州大学化学与分子工程学院,河南郑州450001

出　　处：《合成化学》2020年第11期971-976,共6页Chinese Journal of Synthetic Chemistry

基　　金：河南省教育厅高等学校重点科研项目(20B350009)。

摘　　要：以甜菊苷为原料,经水解、酯化、Fischer法合成了11个新型异斯特维醇吲哚衍生物3a^3k。探索出水解反应的中试条件,开发了石油醚/乙酸乙酯混合溶剂法重结晶精制化合物2,Fischer吲哚合成法合成的目标产物收率为64%~93%,结构经1H NMR、HR-MS和FT-IR表征。Eleven novel isosteviol-indole derivatives 3a^3k were synthesized by acid hydrolysis,esterification and Fischer reactions from stevioside.The pilot-scale experimental conditions for the hydrolysis reaction was explored,and compound 2 was refined by the petroleum ether and ethyl acetate as mixed solvent.The yields of target products 3a^3k,synthesized by Fischer method,were 64%~93%.The structures were characterized by 1H NMR,HR-MS and FT-IR.

关 键 词：异斯特维醇 吲哚 合成 甜菊苷 Fischer法 

分 类 号：O621.3[理学—有机化学] O626.13[理学—化学]