腹膜假黏液瘤的基础研究进展  

Advance on the Basic Research of Pseudomyxoma Peritonei

作　　者：顾依然 杨华[2] 陆维祺[2] 关淼 张伟[3] 史国华[1] 孙正龙 GU Yi-ran;YANG Hua;LU Wei-qi;GUAN Miao;ZHANG Wei;SHI Guo-hua;SUN Zheng-long(Jiangsu Key Laboratory of Medical Optics,Suzhou Institute of Biomedical Engineering and Technology,Chinese Academy of Sciences,Suzhou 215163,China;Shanghai Public Health Clinical Center/Zhongshan Hospital(South Branch),Fudan University,Shanghai 200083,China;The Second Affiliated Hospital of Soochow University,Suzhou 215000,China)

机构地区：[1]中国科学院苏州生物医学工程技术研究所,江苏省医用光学重点实验室,江苏苏州215163 [2]上海公共卫生临床中心/复旦大学附属中山医院南院,上海200083 [3]苏州大学附属第二医院,江苏苏州215000

出　　处：《肿瘤学杂志》2020年第10期907-913,共7页Journal of Chinese Oncology

基　　金：中国科学院苏州生物医学工程技术研究所自主科研项目(Y852123205);中国科学院苏州生物医学工程技术研究所医工结合项目(Y9550201);上海市公共卫生临床中心科研启动基金(KY-GW-2017-12)。

摘　　要：腹膜假黏液瘤是黏液癌的一种罕见亚型,大部分临床病例由阑尾黏液肿瘤在腹腔种植引发。腹膜假黏液瘤的发病机制仍不清楚,当前的临床治疗手段无法有效避免其复发。全文论述近年来腹膜假黏液瘤的基础研究进展,主要包括腹膜假黏液瘤动物模型研究、腹膜假黏液瘤中黏液分泌相关信号通路、降解黏液的物理化学方法研究,以及腹膜假黏液瘤中的基因突变研究等,以期为腹膜假黏液瘤的临床治疗提供参考。Pseudomyxoma peritonei(PMP)is a rare subtype of mucinous adenocarcinoma.Most of the clinical PMP cases are caused by appendiceal mucinous neoplasms implantation in the abdominal cavity.The pathogenesis of PMP remains unclear.Current clinical treatments cannot effectively avoid PMP’s recurrence.This paper reviews the recent basic research progress of PMP,including the animal models of PMP,the signal pathways involved in mucus secretion of PMP,the physicochemical methods for mucus degradation,and the genetic mutations in PMP,in order to provide valuable references for clinical therapeutic strategies of PMP.

关 键 词：腹膜假黏液瘤 阑尾黏液性肿瘤 基因突变 人源性异种移植 

分 类 号：R735.5[医药卫生—肿瘤]