The influence of rs139416141 in neighbor of Brcal gene(NBR1)on bone mineral density in postmenopausal Chinese women  

作　　者：Yang Zhang Zhenlin Zhang Zinan Zhang Lijie Zhao Ying Xue Haojie Wu Jianming Hou 

机构地区：[1]Shengli Clinical Medical College of Fujian Medical University,Fuzhou 350001,China [2]Deptpartment of Osteoporosis and Bone Disease,Metabolic Bone Disease and Genetic Research Unit,Shanghai Jiao Tong University Affiliated Six Peoples Hospital,Shanghai 200233,China [3]Department of Neurological Rehabilitation,The Second Rehabilitation Hospital of Shanghai,Shanghai 200431,China [4]Department of Geriatrics,General Hospital of Daqing Oil Field,Daqing 163311,China [5]Endocrinology Department,Fujian Provincial Hospital,Fuzhou 350001,China

出　　处：《Acta Biochimica et Biophysica Sinica》2020年第9期1047-1049,共3页生物化学与生物物理学报（英文版）

基　　金：the grant from the National Natural Science Foundation of China(No.81770871).

摘　　要：Bone mineral density(BMD)is used to assess bone mass at present and〜70%of the variance is determined by genetic factors[1].BMD in a lifetime is in a dynamic change from peak values obtained during growth to a gradual decrease during postmenopause and aging.Bone micro-architecture deterioration in postmenopausal women is a result of in creased bone remodeling and liable to&acture of the hip,wrist and spine[2].This bone remodeling imbalance due to estrogen deficiency causes skeletal tissues in the state of enhancement of osteoclastogenesis and impairment of osteogenesis.

关 键 词：POSTMENOPAUSAL REMODELING IMPAIRMENT 

分 类 号：R681[医药卫生—骨科学]