Recent progress in enzymatic functionalization of carbon-hydrogen bonds for the green synthesis of chemicals  

作　　者：Zheyu Wang Yupei Jian Yilei Han Zhongwang Fu Diannan Lu Jianzhong Wu Zheng Liu 

机构地区：[1]Key Lab of Industrial Biocatalysis,Ministry of Education,Department of Chemical Engineering,Tsinghua University,Beijing 100084,China [2]Department of Chemical and Environmental Engineering,University of California,Riverside,CA 92521,USA

出　　处：《Chinese Journal of Chemical Engineering》2020年第10期2499-2506,共8页中国化学工程学报（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.21676157 and No.21520102008)。

摘　　要：Enzymatic reactions take place with high chemo-, regio-, and stereo-selectivity, appealing for the direct functionalization of abundant and inexpensive compounds with C-H bonds to make fine chemicals such as high-value intermediates and pharmaceuticals. This review summarizes recent progress in the enzymatic functionalization of C-H bonds with an emphasis on heme enzymes such as cytochrome P450 s, chloroperoxidase and unspecific peroxygenases. Specific examples are discussed to elucidate the applications of the molecular and process engineering approaches to overcome the challenges hindering enzymatic C-H functionalization. Also discussed is the recent development of the chemo-enzymatic cascade as an effective way to integrate the power of metal catalysis and enzymatic catalysis for C-H functionalization.

关 键 词：BIOCATALYSIS Biochemical engineering ENZYME C-H functionalization CHLOROPEROXIDASE 

分 类 号：TQ426.97[化学工程]