Genes associated with Alzheimer's disease affecting ischemic neurodegeneration of the hippocampal CA3 region  

作　　者：Ryszard Pluta Marzena Ułamek-Kozioł 

机构地区：[1]Laboratory of Ischemic and Neurodegenerative Brain Research,Mossakowski Medical Research Centre,Polish Academy of Sciences,Warsaw,Poland

出　　处：《Neural Regeneration Research》2021年第7期1392-1393,共2页中国神经再生研究（英文版）

基　　金：supported by the Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland(to RP)。

摘　　要：Neurodegeneration in the brain after ischemia with reperfusion mimicking the neuropathology of Alzheimer's disease:Brain ischemia with reperfusion,which is one of the main causes of morbidity and mortality in the world,triggers various neuropathological changes characteristic for Alzheimer's disease(AD)such as increased blood-brain barrier permeability,excitotoxicity,necrosis,autophagy,mitophagy,apoptosis,neuroinflammation,amyloid plaques,neurofibrillary tangles,cerebral vessel pathology,and brain atrophy that lead to the death of neurons,deteriorating motor,sensory and cognitive functions(Figure 1)(Kato et al.,1988;Wisniewski et al.,1995;Van Groen et al.,2005;Kocki et al.,2015;Ułamek-Koziołet al.,2016,2017,2019).Brain ischemia is recognized as a major contributor to the dysfunction of an aging brain and the development of neurodegenerative diseases,including AD(Pluta,2019).

关 键 词：ALZHEIMER ISCHEMIA cerebral 

分 类 号：R749.16[医药卫生—神经病学与精神病学]