β-烟酰胺单核苷酸合成技术研究进展  

Advance in Synthesis of β-Nicotinamide Mononucleotide

作　　者：张颖 蒋雨馨 朱逸浩 吴剑荣 ZHANG Ying;JIANG Yuxin;ZHU Yihao;WU Jianrong(Key Laboratory of Carbohydrate Chemistry and Biotechnology,Ministry of Education,School of Biotechnology,Jiangnan University,Wuxi 214122,China)

机构地区：[1]江南大学生物工程学院,糖化学与生物技术教育部重点实验室,江苏无锡214122

出　　处：《食品科技》2020年第10期236-240,共5页Food Science and Technology

基　　金：国家科技支撑计划项目(2007BAK36B03);江苏省大创项目(201910295116Y)。

摘　　要：β-烟酰胺单核苷酸(NMN)是哺乳动物体内烟酰胺腺嘌呤二核苷酸补救合成途径的前体物质。研究表明,烟酰胺单核苷酸在延缓衰老、治疗帕金森等老年病、调节胰岛素分泌、调控mRNA的表达等方面具有医疗保健效果。近年研究发现,人为补充NMN可以修复脑损伤、改善胰岛功能、保护心脏免于缺血再灌注损伤、修复脑线粒体呼吸缺陷,对老年退行性疾病、视网膜退行性疾病等均具有一定治疗作用。但是受限于合成工艺,NMN原料价格昂贵。目前,化学合成法制备NMN的技术较为成熟,但是存在食品安全、产生手性化合物和环保等问题;生物催化法合成NMN能更好地避开这些缺陷,但是需要解决能量供给带来的成本问题。β-Nicotinamide mononucleotide(NMN)is a precursor of the nicotinamide adenine dinucleotide salvage pathway in mammals.Studies have shown that NMN has a health care effect in delaying aging,treating senile diseases such as Parkinson’s,regulating insulin secretion and regulating mRNA expression.In recent years,supplementation of NMN in dietary was proved to repair brain damage,improve islet function,protect heart from ischemia-reperfusion injury,repair brain mitochondrial respiratory defects,and have certain therapeutic effects on senile degenerative diseases and retinal degenerative diseases.However,due to limitation of current chemical synthesis,raw NMN are expensive.At present,the technology for NMN preparation by chemical synthesis is relatively mature,but the problems such as food safety,chirality and environment protection remain,the synthesis of NMN by biocatalysis can better avoid these problems,but it needs to solve the capital cost from energy supply.

关 键 词：烟酰胺单核苷酸 化学合成 生物合成 酶法合成 抗衰老 

分 类 号：TS201.2[轻工技术与工程—食品科学]