华裔中年女性每日总维生素B12摄入量与焦虑症的关系  

The relationship between daily total vitamin B12 intake and anxiety disorders in middle⁃aged Chinese women

作　　者：徐万洲[1] 李迪[1] 吴青[1] 李艳[1] XU Wanzhou;LI Di;WU Qing;LI Yan(Department of Clinical Laboratory,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China)

机构地区：[1]武汉大学人民医院检验科,湖北武汉430060

出　　处：《安徽医药》2020年第12期2527-2531,共5页Anhui Medical and Pharmaceutical Journal

基　　金：国家临床重点专科建设项目资助(财社〔2010〕305号)。

摘　　要：目的研究华裔中年女性每日维生素B12(vitamin B12,VB12)摄入量与焦虑症的关系。方法本研究数据来自美国妇女健康研究(Study of Women’s Health Across the Nation,SWAN)。焦虑症通过参与者自评量表的方式评估,维生素B(B1,B2,B3,B6,B9,B12)的每日摄入量由1986年版饮食频率调查问卷推算,Fisher确切概率法比较组间率的差异,Mann⁃Whitney U比较两组变量通体均值的差异,logistic回归分析VB12与焦虑症之间的关系,限制性三次样条分析两者的非线性关系。结果在纳入研究的241例女性中,10例(4.1%)患有焦虑症。焦虑组倾向有更高的脉搏和总胆固醇(P分别为0.034,0.009)。焦虑组女性的每日总VB12摄入量的中位数(下、上四分位数)为1.78(1.01,2.03)μg/d,低于对照组的2.34(1.47,3.27)μg/d(P=0.027)。在焦虑组中,符合VB12每日膳食营养素推荐供给量(RDA)标准的女性少于对照组(P=0.023)。总VB12摄入量与焦虑症呈负相关关系,且低水平VB12摄入量人群发生焦虑症的风险更高(OR=10.25,95%CI:1.28~82.22)。在调节了年龄后,这种关系依然存在。在充分调整潜在混杂因素年龄、脉搏和总胆固醇后,总VB12摄入量仍然与焦虑症负相关(OR=0.36,95%CI:0.15~0.84)。此外,低水平VB12摄入量的焦虑症风险更高(OR=19.42,95%CI:2.08~180.98)。符合VB12摄入量RDA标准的人群发生焦虑症的风险低于VB12摄入量不足人群(OR=0.12,95%CI:0.02~0.98)。在调整协变量后,这种关系依然存在(OR=0.08,95%CI:0.01~0.66)。限制性三次样条表明,随着VB12摄入量的增高,焦虑症发生风险先处于平台期,随后逐渐下降。结论总VB12摄入量与焦虑症呈负相关关系。由于是横断面研究,因此VB12可能是焦虑症的保护因素;而低水平VB12也可能是焦虑症所致。Objective To study the relationship between daily vitamin B12 intake and anxiety disorders in middle⁃aged Chinese women.Methods Data used in present study were from Study of Women’s Health Across the Nation(SWAN).Anxiety disorders were assessed by participant self⁃rating scale.Daily intake amounts of vitamin B(B1,B2,B3,B6,B9,B12)were calculated based on 1986 version of food⁃frequency questionnaire.Fisher precise probability method was used to compare the differences in inter⁃group rates.Mann⁃Whitney U was used to compare the difference in general means of variables between the two groups.The associa⁃tion of VB12 intake with anxiety was examined using logistic regression analysis and the non⁃lineal relationship was analyzed by re⁃stricted cubic splines.Results Of the 241 women included in the study,10(4.1%)suffered from anxiety.Pulse and total cholester⁃ol tended to be higher in anxiety group than the control group(P=0.034,0.009).The median(lower quartile,upper quartile)of dai⁃ly intake of vitamin B12 in anxiety group was lower than that in control group[1.78(1.01,2.03)μg/d vs.2.34(1.47,3.27)μg/d,P=0.027].In anxiety group,fewer women met the vitamin B12 recommended dietary allowance(RDA)standard than the control group(P=0.023).There was a negative correlation of total vitamin B12 intake with anxiety disorders.People with lower vitamin B12 intake had a higher risk of developing anxiety disorder(OR=10.25,95%CI:1.28⁃82.22).After ageadjustment,such relation⁃ship still existed.Negative correlation of total vitamin B12 intake with anxiety disorders still existed after the adjustment of potential confounding factors such as age,pulse and total cholesterol(OR=0.36,95%CI:0.15⁃0.84).Besides,lower vitamin B12 intake was associated with a higher risk of anxiety disorders(OR=19.42,95%CI:2.08⁃180.98).The risk of anxiety in people who met vitamin B12 intake RDA criteria was lower than that in people who had insufficient vitamin B12 intake(OR=0.12,95%CI:0.02⁃0.98).Af⁃ter adjusting the covariate

关 键 词：焦虑症 膳食调查 维生素B12 危险因素 横断面研究 女性 亚裔美国人 

分 类 号：R749.72[医药卫生—神经病学与精神病学]