血清外泌体中NY-ESO-1,Alix,PLAP联合对非小细胞肺癌的诊断价值  

Diagnostic value of NY-ESO-1,Alix,PLAP in serum exosomes for non-small cell lung cancer

作　　者：王娟 潘鑫 徐永茂 WANG Juan;PAN Xin;XU Yongmao(Department of Hematology and Endocrinology,the 71st Military Hospital of the Army,Xuzhou 221009,Jiangsu,China;Department of Tumor Hematology,the 71st Military Hospital of the Army,Xuzhou 221009,Jiangsu,China)

机构地区：[1]陆军第七十一集团军医院血液内分泌科,江苏徐州221009 [2]陆军第七十一集团军医院肿瘤血液科,江苏徐州221009

出　　处：《中南医学科学杂志》2020年第6期633-636,共4页Medical Science Journal of Central South China

摘　　要：探讨血清外泌体中纽约食管鳞状细胞癌抗原-1(NY-ESO-1)、Alix、胎盘碱性磷酸酶(PLAP)联合对非小细胞肺癌的诊断价值。将早期非小细胞肺癌患者设为肺癌组、肺部良性疾病患者设为良性组、体检健康者设为对照组。结果显示,血清外泌体中NY-ESO-1,Alix,PLAP鉴别早期非小细胞肺癌患者与肺部良性疾病患者的灵敏度分别为98%、95%和90%,特异度分别为78%,80%,90%。鉴别早期非小细胞肺癌患者与健康体检者的灵敏度分别为95%,94%,95%,特异度分别为95%,95%,92%。联合鉴别早期非小细胞肺癌的诊断的的灵敏度为95.00%,特异度为91.00%,准确度为92.33%。结果说明,血清外泌体中NY-ESO-1,Alix,PLAP的表达量检测可作为诊断早期非小细胞肺癌的潜在标志。To investigate the diagnostic value of New York-esopHageal-1(NY-ESO-1),Alix,placental alkaline phosphatase(PLAP)in serum exosomes for non-small cell lung cancer(NSCLC).The early NSCLC patients were divided into cancer group,benign lung disease group and control group.The results showed that the sensitivity of NY-ESO-1,Alix and PLAP in serum exosomes was 98%,95%and 90%respectively,and the specificity was 78%,80%and 90%respectively.The sensitivity was 95%,94%,95%and the specificity was 95%,95%,92%respectively.The sensitivity,specificity and accuracy of the combined diagnosis were 95.00%,91.00%and 92.33%respectively.The expression of NY-ESO-1,Alix and PLAP in serum exosomes can be used as a potential marker for early diagnosis of NSCLC.

关 键 词：血清 外泌体 纽约食管鳞状细胞癌-1 ALIX 胎盘碱性磷酸酶 非小细胞肺癌 诊断 

分 类 号：R734.2[医药卫生—肿瘤]