类风湿关节炎动物模型研究进展  

Research progress on animal models of rheumatoid arthritis

作　　者：夏晴 纪羽婷[1] 刘海亮 宋武琦[1] XIA Qing;JI Yuting;LIU Hailiang;SONG Wuqi(Department of Microbiology,Harbin Medical University,Wu Lien-Teh Institute,the Heilongjiang Key Laboratory of Immunity and Infection,the Key Laboratory of Pathogenic Biology,Heilongjiang Higher Education Institutions,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学微生物学教研室,伍连德研究所,黑龙江省免疫与感染重点实验室,黑龙江省普通高校病原生物学重点实验室,哈尔滨150081

出　　处：《中国比较医学杂志》2020年第11期107-113,共7页Chinese Journal of Comparative Medicine

基　　金：国家重点研发项目(2017YFB0403805)。

摘　　要：类风湿关节炎是一种多发性自身免疫性疾病,多累及关节,最终会导致关节的畸形,在自然病程中,10年致残率可超过60%,严重影响生活质量。类风湿关节炎的动物模型在其发病机制、治疗方法、治疗靶点等方面的研究中发挥重要作用。本综述主要介绍几种常见类风湿关节炎动物模型的构建方法、发病机制及其应用,以便在今后的疾病研究中选择合适的动物模型。Rheumatoid arthritis(RA),an autoimmune disease,affects the joints and eventually leads to joint deformity.Without intervention,the disability rate can exceed 60%over 10 years,which seriously affects the quality of life of patients.Animal models of RA have played an important role in the study of the pathogenesis,treatment,and identification of therapeutic targets of RA.In this review,the construction method,pathogenesis,and applications of several common animal models of RA are introduced to aid researchers in selecting appropriate animal models for future disease research.

关 键 词：类风湿关节炎 动物模型 佐剂诱导 胶原诱导 降植烷诱导 软骨寡聚基质蛋白诱导 基因工程 

分 类 号：R-33[医药卫生]