Palladium-Catalzyed Atroposelective 16-Membered Macrocyclization: Total Synthesis of lsoplagiochin D  

作　　者：Junwei Xi Zhenhua Gu 

机构地区：[1]Hefei National Laboratory for Physical Sciences ot the Microscale,and Department of Chemistry,University of Science and Technology of China,96 Jinzhai Rood,Hefei,Anhui 230026,China [2]Center for Excellence in Molecular Synthesis of CAS,Hefei,Anhui 230026,China

出　　处：《Chinese Journal of Chemistry》2020年第10期1081-1085,共5页中国化学（英文版）

基　　金：This work was financially supported by the National Natural Science Foundation of China(No.21871241);the Fundamental Research Funds for the Central Universities(WK2060190086).

摘　　要：Summary of main observation and conclusion Isoplagiochin D is a ring-strained macrocyclic bisbibenzylis,which showed stable axial chirality in one biaryl structure,and semistable axial chirality in the other biaryl moiety.We reported here an unprecedented example for the catalytically asymmetric synthesis of ring-strained atropisomers via Pd-catalyzed macrocyclization between benzyl halides and carbenes.This newly developed Pd-catalyzed asym-metric macrocyclization protocol enabled us a quick synthesis of isoplagiochin D in a highly enantioselective manner.

关 键 词：CYCLIZATION BENZYL CATALYZED 

分 类 号：O62[理学—有机化学]