Effects of Pitavastatin on Lipoprotein Subfractions and Oxidized Low-density Lipoprotein in Patients with Atherosclerosis  

作　　者：Rui-xia XU Yan ZHANG Yue ZHANG Ya-ru WU Xiao-lin LI Yuan-lin GUO Geng LIU Qian DONG Jian-jun LI 

机构地区：[1]State Key Laboratory of Cardiovascular Disease,Fu Wai Hospital National Center for Cardiovascular Disease,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China

出　　处：《Current Medical Science》2020年第5期879-884,共6页当代医学科学（英文）

基　　金：This work was supported,in part,by Capital Special Foundation of Clinical Application Research(No.Z121107001012015);Capital Health Development Fund(No.201614035);CAMS Major Collaborative Innovation Project(No.2016-I2M-1-011);PUMC Youth Fund(No.3332018200).

摘　　要：It has been demonstrated that pitavastatin can significantly reduce low-density lipoprotein(LDL)cholesterol(LDL-C),but its impact on lipoprotein subfractions and oxidized low-density lipoprotein(oxLDL)has not been determined.The aim of the present study was to investigate the potential effects of pitavastatin on subfractions of LDL and high-density lipoprotein(HDL)as well as oxLDL in untreated patients with coronary atherosclerosis(AS).Thirty-six subjects were enrolled in this study.O f them,18 patients with AS were administered pitavastatin 2 mg/day for 8 weeks and 18 healthy subjects without therapy served as controls.The plasma lipid profile,lipoprotein subfractions and circulating oxLDL were determined at baseline and 8 weeks respectively.The results showed that pitavastatin treatment indeed not only decreased LDL-C,total cholesterol(TC),triglycerides(TG)and apolipoprotein B(ApoB)levels,and increased HDL cholesterol(HDL-C),but also reduced the cholesterol concentration of all of the LDL subfractions and the percentage of intermediate and small LDL subfractions.Meanwhile,pitavastatin could decrease plasma oxLDL levels.Furthermore,a more close correlation was found between oxLDL and LDL-C as well as LDL subfractions after pitavastatin treatment.We concluded that a moderate dose of pitavastatin therapy not only decreases LDL-C and oxLDL concentrations but also improves LDL subfractions in patients with AS.

关 键 词：PITAVASTATIN ATHEROSCLEROSIS lipoprotein subfraction low-density lipoprotein 

分 类 号：R54[医药卫生—心血管疾病]