CYLD在细胞功能及肿瘤进程中的调控作用研究  

Study on the Regulation of CYLD in Cell Function and Tumor Process

作　　者：苗瑞 鲍秀琦[1] 杨成昆 布琼 彭博[1] Miao Rui;Bao Xiuqi;Yang Chengkun;Bu Qiong;Peng Bo(First Hospital Affiliated to Jiamusi University,Jiamusi 154003,China)

机构地区：[1]佳木斯大学附属第一医院,黑龙江佳木斯154003

出　　处：《广东化工》2020年第21期81-82,共2页Guangdong Chemical Industry

摘　　要：头帕肿瘤综合征蛋白因具有肿瘤抑制因子的作用而被广泛研究。圆柱瘤病基因CYLD编码的活性蛋白是一种细胞内多功能去泛素化酶,能去除特定底物的RIP1、TRAFs、NEMO和Bcl-3等信号分子及K63泛素链[1],可抑制多聚泛素依赖性信号通路,包括促炎和促进细胞生长的NF-KB通路、JNK等信号通路[2]。从而参与了促炎反应、恶性细胞增殖与分化、细胞凋亡等,在肿瘤发生发展过程中发挥抑癌基因的作用。Scalp tumor syndrome protein has been widely studied for its role as a tumor suppressor. Cylinomatosis gene CYLD encodes an active protein that is a multifunctional deubiquitinating enzyme in the cell. It can remove signaling molecules such as RIP1, TRAFs, NEMO, and Bcl-3, and K63 ubiquitin chains, which can inhibit polymerization Ubiquitin-dependent signaling pathways include NF-κB pathways, JNK and other signaling pathways that promote inflammation and cell growth. It is involved in pro-inflammatory response, malignant cell proliferation and differentiation, and apoptosis, and plays a role as a tumor suppressor gene in the process of tumorigenesis and development.

关 键 词：圆柱瘤 肿瘤 泛素化 NF-KB 

分 类 号：R730.2[医药卫生—肿瘤]