Melanin change of retinal pigment epithelium and choroid in the convalescent stage of Vogt-Koyanagi-Harada disease  

作　　者：Ying Huang Ya-Ting Yang Bing Lin Sheng-Hai Huang Zu-Hua Sun Rong Zhou Ying-Zi Li Xiao-Ling Liu 

机构地区：[1]School of Ophthalmology&Optometry and Eye Hospital,Wenzhou Medical University,Wenzhou 325027,Zhejiang Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2020年第12期1928-1932,共5页国际眼科杂志（英文版）

摘　　要：AIM:To observe the melanin change of the retinal pigment epithelium(RPE)and choroid in the convalescent stage of Vogt-Koyanagi-Harada(VKH).METHODS:A retrospective study was performed on 40 eyes of 20 patients in the convalescent stage of VKH.Fundus photography(FP),multi-spectral imaging(MSI),and optical coherence tomography(OCT)were performed.RESULTS:In the VKH convalescent stage,focal RPE melanin accumulation(FRMA)was detected in 34 eyes(85%)on MSI and in 7 eyes(17.5%)on FP.FRMA was limited to the previous retinal detachment area in all 28 eyes(FRMA was detected in 34 eyes on MSI,which were enrolled,and 6 eyes lacked data in the acute stage).Sunset-glow fundus was detected in 20 eyes(50%)on FP.The mean density of FRMA in a 1-mm-diameter circular area of the fovea was 0.04±0.07 on MSI,which was significantly correlated with sunset-glow fundus(ρ=0.467,P=0.02).CONCLUSION:In the VKH convalescent stage,FRMA is derived from the RPE melanin change,and sunset-glow fundus is derived from the choroid melanin change.A higher density of FRMA in the fovea and sunset-glow fundus represents more serious depigmentation of melanin.

关 键 词：MELANIN retinal pigment epithelium CHOROID convalescent stage VOGT-KOYANAGI-HARADA 

分 类 号：R774.1[医药卫生—眼科]