A DNA Nanodevice for Cancer Vaccination  

作　　者：ZUO Hua MAO Chengde 

机构地区：[1]College of Pharmaceutical Sciences,Southwest University,Chongqing 400716,P.R.China [2]Department of Chemistry,Purdue University,West Lafayette,Indiana 47907,United States

出　　处：《Chemical Research in Chinese Universities》2020年第6期1147-1148,共2页高等学校化学研究（英文版）

摘　　要：To realize effective cancer immunotherapy,Ding et al.constructed a structurally well-defined DNA-based nanodevice to quantitatively assemble cancer cell-specific antigen and multiple adjuvants as a cancer vaccine.This nanodevice vaccine can efficiently accumulate in the draining lymph nodes and respond to the endosomal acidic environment of dendritic cells to release the antigen and adjuvants.These active payloads stimulate dendritic cells maturation and antigen presentation to elicit a robust,antigen-specific cytotoxic T-lymphocyte response to kill cancer cells.This work has been published online in the Nature Materials on Sept.7,2020.

关 键 词：VACCINE al. CANCER 

分 类 号：R186[医药卫生—流行病学]