Mesenchymal stem cells secretome:The cornerstone of cell-free regenerative medicine  

作　　者：Alberto González-González Daniel García-Sánchez Monica Dotta JoséC Rodríguez-Rey Flor M Pérez-Campo 

机构地区：[1]Department of Molecular Biology_IDIVAL,Faculty of Medicine,University of Cantabria,Santander 39011,Cantabria,Spain

出　　处：《World Journal of Stem Cells》2020年第12期1529-1552,共24页世界干细胞杂志（英文版）（电子版）

基　　金：Supported by Spanish Ministerio de Economía y competitividad,No.RTI2018-097324;Predoctoral program in Biomedicine from the University of Cantabria and the Instituto de Investigación Valdecilla(IDIVAL),No.PREVAL 19/02 and PREVAL 20/01.

摘　　要：Mesenchymal stem cells(MSCs)are the most frequently used stem cells in clinical trials due to their easy isolation from various adult tissues,their ability of homing to injury sites and their potential to differentiate into multiple cell types.However,the realization that the beneficial effect of MSCs relies mainly on their paracrine action,rather than on their engraftment in the recipient tissue and subsequent differentiation,has opened the way to cell-free therapeutic strategies in regenerative medicine.All the soluble factors and vesicles secreted by MSCs are commonly known as secretome.MSCs secretome has a key role in cell-to-cell communication and has been proven to be an active mediator of immunemodulation and regeneration both in vitro and in vivo.Moreover,the use of secretome has key advantages over cell-based therapies,such as a lower immunogenicity and easy production,handling and storage.Importantly,MSCs can be modulated to alter their secretome composition to better suit specific therapeutic goals,thus,opening a large number of possibilities.Altogether these advantages now place MSCs secretome at the center of an important number of investigations in different clinical contexts,enabling rapid scientific progress in this field.

关 键 词：Mesenchymal stem cells SECRETOME Soluble factors Extra-cellular vesicles EXOSOMES Bone regeneration 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]