Invasive fungal infection before and after liver transplantation  

作　　者：Alberto Ferrarese Annamaria Cattelan Umberto Cillo Enrico Gringeri Francesco Paolo Russo Giacomo Germani Martina Gambato Patrizia Burra Marco Senzolo 

机构地区：[1]Multivisceral Transplant Unit,Padua University Hospital,Padua 35128,Italy [2]Tropical and Infectious Disease Unit,Padua University Hospital,Padua 35128,Italy [3]Padua University Hospital,Hepatobiliary Surgery and Liver Transplant Center,Padua 35128,Italy

出　　处：《World Journal of Gastroenterology》2020年第47期7485-7496,共12页世界胃肠病学杂志（英文版）

摘　　要：Invasive infections are a major complication before liver transplantation(LT)and in the early phase after surgery.There has been an increasing prevalence of invasive fungal disease(IFD),especially among the sickest patients with decompensated cirrhosis and acute-on-chronic liver failure,who suffer from a profound state of immune dysfunction and receive intensive care management.In such patients,who are listed for LT,development of an IFD often worsens hepatic and extra-hepatic organ dysfunction,requiring a careful evaluation before surgery.In the post-transplant setting,the burden of IFD has been reduced after the clinical advent of antifungal prophylaxis,even if several major issues still remain,such as duration,target population and drug type(s).Nevertheless,the development of IFD in the early phase after surgery significantly impairs graft and patient survival.This review outlines presentation,prophylactic and therapeutic strategies,and outcomes of IFD in LT candidates and recipients,providing specific considerations for clinical practice.

关 键 词：Acute-on-chronic liver failure SEPSIS CIRRHOSIS CANDIDEMIA Acute liver failure Invasive fungal infection 

分 类 号：R657.3[医药卫生—外科学] R519[医药卫生—临床医学]