Idiopathic adulthood ductopenia with elevated transaminase only:A case report  

作　　者：Xiao-Chen Zhang Di Wang Xiang Li Yu-Lin Hu Chong Wang 

机构地区：[1]Department of Hepatology,The First Hospital of Jilin University,Changchun 130021,Jilin Province,China

出　　处：《World Journal of Clinical Cases》2020年第24期6524-6528,共5页世界临床病例杂志

摘　　要：BACKGROUND Idiopathic adulthood ductopenia (IAD) is a chronic cholestatic liver disease ofunknown etiology that usually presents as unexplained jaundice. It ischaracterized by adult onset, lack of autoantibodies, inflammatory bowel diseaseand loss of interlobular bile ducts.CASE SUMMARY This case presents a 27-year-old woman with elevation of transaminases andalkaline phosphatase without clinical symptoms. Five years ago, the patient hadabnormal transaminases but no cholestasis. Three months before admission,physical examination revealed an increase in transaminases. Oralhepatoprotective drugs did not show any significant improvement, and she wasadmitted to hospital for further diagnosis and treatment. Liver biopsy confirmedIAD. After about 2 wk of ursodeoxycholic acid treatment, serological andhistological examination showed a significant response.CONCLUSION IAD is a manifestation of cholestasis, but also may be an abnormal increase intransaminase in the early stage.

关 键 词：Idiopathic adulthood ductopenia Ductopenic diseases Liver injury CHOLESTASIS Ursodeoxycholic acid Case report 

分 类 号：R575.7[医药卫生—消化系统]