Amyloid hypothesis through the lens of Aβ supersaturation  

作　　者：Zhefeng Guo 

机构地区：[1]Department of Neurology,Brain Research Institute,Molecular Biology Institute,University of California,Los Angeles,CA,USA

出　　处：《Neural Regeneration Research》2021年第8期1562-1563,共2页中国神经再生研究（英文版）

基　　金：supported by the National Institute of Health,USA (No. R01AG050687)。

摘　　要：Deposition of aggregated amyloid-β(Aβ)protein in the form of amyloid plaques is a pathological hallmark of Alzheimer's disease.According to the amyloid hypothesis,Aβaggregation initiates a pathogenic cascade,eventually leading to dementia.Being the prevailing theory for Alzheimer's disease,amyloid hypothesis has been used to guide basic research and therapeutic interventions.Supersaturation is a phenomenon that occurs when the concentration of a solute in the solution exceeds its thermodynamic solubility.In the brain,Aβ proteins are usually supersaturated.Aβ aggregation follows the principle of supersaturation(So et al.,2016).

关 键 词：AΒ AMYLOID ALZHEIMER 

分 类 号：R749.16[医药卫生—神经病学与精神病学]