ISP and PAP4 peptides promote motor functional recovery after peripheral nerve injury  

作　　者：Shi-Qin Lv Wutian Wu 

机构地区：[1]Guangdong-Hong Kong-Macao Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan University,Guangzhou,Guangdong Province,China [2]Re-Stem Biotechnology Co.,Ltd.,Suzhou,Jiangsu Province,China

出　　处：《Neural Regeneration Research》2021年第8期1598-1605,共8页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No. 81971165;the National Basic Research Program of China (973 Program),No. 2014CB542205 (both to WW)。

摘　　要：Both intracellular sigma peptide(ISP) and phosphatase and tensin homolog agonist protein(PAP4) promote nerve regeneration and motor functional recovery after spinal cord injury. However, the role of these two small peptides in peripheral nerve injury remains unclear. A rat model of brachial plexus injury was established by crush of the C6 ventral root. The rats were then treated with subcutaneous injection of PAP4(497 μg/d, twice per day) or ISP(11 μg/d, once per day) near the injury site for 21 successive days. After ISP and PAP treatment, the survival of motoneurons was increased, the number of regenerated axons and neuromuscular junctions was increased, muscle atrophy was reduced, the electrical response of the motor units was enhanced and the motor function of the injured upper limbs was greatly improved in rats with brachial plexus injury. These findings suggest that ISP and PAP4 promote the recovery of motor function after peripheral nerve injury in rats. The animal care and experimental procedures were approved by the Laboratory Animal Ethics Committee of Jinan University of China(approval No. 20111008001) in 2011.

关 键 词：AXON brachial plexus injury crush injury intracellular sigma peptide motor function PAP4 peripheral nerve protection regeneration repair 

分 类 号：R745[医药卫生—神经病学与精神病学]