Effect of non-alcoholic beer,diet and exercise on endothelial function,nutrition and quality of life in patients with cirrhosis  

作　　者：Ricardo U Macias-Rodriguez Astrid Ruiz-Margain Berenice M Roman-Calleja May E Espin-Nasser Nayelli CFlores-Garcia Aldo Torre Gretel Galicia-Hernandez Silvia L Rios-Torres Gabriela Fernandez-del-Rivero Arturo Orea-Tejeda Oscar A Lozano-Cruz 

机构地区：[1]Department of Gastroenterology,Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran,Mexico City 14080,Mexico [2]Liver Fibrosis and Nutrition Lab(LFN-Lab),MICTLÁN Network:Mechanisms of Liver Injury,Cell Death and Translational Nutrition in Liver Diseases-Research Network,Mexico City 14080,Mexico [3]Department of Cardiology,Instituto Nacional de Enfermedades Respiratorias,Mexico City 14080,Mexico [4]Department of Internal Medicine,Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran,Mexico City 14080,Mexico

出　　处：《World Journal of Hepatology》2020年第12期1299-1313,共15页世界肝病学杂志（英文版）（电子版）

摘　　要：BACKGROUND The implementation of nutritional strategies targeting several variables at once could benefit patients with cirrhosis.Non-alcoholic beer has different compounds that exert antioxidant,anti-inflammatory and nutritional properties.AIM To evaluate the effect of diet+exercise and non-alcoholic beer on nutritional status,endothelial function and quality of life in patients with cirrhosis.METHODS In this randomized open clinical trial,patients with cirrhosis were randomized into two groups:The intervention(non-alcoholic beer+diet+exercise)and control(water+diet+exercise)group.Treatment consisted of 330 mL nonalcoholic beer/day or the same amount of water,plus an individualized dietary plan and an exercise program with a pedometer-based bracelet to reach at least 5000 steps/d and>2500 above the baseline during 8 wk.Endothelial function(flow-mediated dilation,plethysmography),biochemical and nutritional variables and quality of life(CLDQ)were evaluated.RESULTS Forty-three patients were included in the study,21 in the control group and 22 in the intervention group.The mean age was 53.5±7.8 years,60%were women,the median MELD score was 8(7-10)and most patients were Child-Pugh A(88%).Adherence to the interventions was>90%in both groups,there were no adverse events and all biochemical parameters remained stable in both groups.Endothelial function improved in both groups.All measured nutritional parameters improved in the intervention group,compared to only 2 in the control group and quality of life improved in both groups;however,more domains improved in the intervention group.CONCLUSION The intervention consisting of non-alcoholic beer,diet and exercise seems to be safe and well tolerated in patients with cirrhosis,and shows improvement in nutritional status,endothelial function,and quality of life.These results need to be further confirmed.

关 键 词：HOPS Portal hypertension SARCOPENIA DIET CIRRHOSIS Antioxidants 

分 类 号：R57[医药卫生—消化系统]