Streptococcus agalactiae:Sensitivity profile in pregnant women attending health units in northeastern Brazil  

作　　者：Tais Viana Ledo de Oliveira Fabrícia Almeida Fernandes Santana Caline Novais Teixeira Oliveira Maria Luísa Cordeiro Santos Fabrício Freire de Melo Cláudio Lima Souza Márcio Vasconcelos Oliveira 

机构地区：[1]Instituto Multidisciplinar em Saúde,Universidade Federal da Bahia,Vitória da Conquista 45029-094,Bahia,Brazil

出　　处：《World Journal of Obstetrics and Gynecology》2020年第1期11-17,共7页世界妇产科杂志

摘　　要：BACKGROUNDG roup B Streptococcus agalactiae (GBS) is the main etiologic agent associated withearly-onset neonatal sepsis, and of all newborns of parturients colonized by GBS,approximately 1%-2% develop invasive, early-onset disease. The risk of infectionincreases to 15.2% in premature neonates, to 10.7% when the parturient haschorioamnionitis or premature rupture of membranes for more than 24 h and to9.7% if the mother has postpartum bacteremia. In addition to causing perinatal,neonatal and postnatal deaths, neonatal hospital infection is associated with highcosts, as hospitalization is three times longer than in uninfected children. Theidentification of pregnant women colonized by GBS, through universal screening,associated with the adoption of appropriate antibiotics at the time of delivery arethe most successful preventive measures.AIMTo evaluate the sensitivity profile of GBS isolated from pregnant womenattending Vitória da Conquista-BA.METHODS This is a cross-sectional study with a quantitative approach carried out in themunicipality of Vitória da Conquista-Bahia between February 2017 and March2018. The study population was composed of 210 pregnant women, with agestational age of 32 to 40 wk, who were aged 18 years or older living in the urbanarea of the municipality of Vitória da Conquista. After a brief explanation aboutthe research and obtaining a signed an informed consent form, data andvaginorectal swabs were collected from the women for GBS research. Examinationof the samples in order to identify the presence of GBS was by culture on sheep blood agar and chromogenic agar for GBS and then, seeded on plates containingstreptococcal culture medium and incubated for 18 h to 24 h at 35°C. Theantimicrobial sensitivity profile of positive GBS samples was determined by thedisk diffusion technique, according to the Clinical and Laboratory StandardsInstitute manual (2017). The data obtained were stored in a database usingMicrosoft Office Excel spreadsheets and a descriptive analysis was performedwith the aid

关 键 词：Streptococcus agalactiae Sensitivity profile PREGNANCY CLINDAMYCIN ERYTHROMYCIN Group B streptococcal disease 

分 类 号：R74[医药卫生—神经病学与精神病学]