吉伯特综合征的诊疗与药学监护  

Diagnosis,treatment and pharmaceutical care of Gilbert syndrome

作　　者：左靖 王龙[2] 孟珺 ZUO Jing;WANG Long;MENG Jun(Department of Pharmacy,Cancer Hospital Chinese Academy of Medical Sciences,Shenzhen Center(National Cancer Center,National Clinical Research Center for Cancer and Cancer Hospital&Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical Sciences and Peking Union Medical College),Guangdong,Shenzhen 518116,China;Department of Anesthesiology,SuZhou Municipal Hospital,Suzhou,Anhui 234000,China)

机构地区：[1]中国医学科学院肿瘤医院深圳医院(国家癌症中心、国家肿瘤临床药学研究中心、中国医学科学院北京协和医学院肿瘤医院深圳医院)药学部,广东深圳518116 [2]宿州市立医院麻醉科,安徽宿州234000

出　　处：《安徽医药》2021年第1期194-197,共4页Anhui Medical and Pharmaceutical Journal

基　　金：深圳市科技计划项目(JCYJ20170307112807219)。

摘　　要：目的分析吉伯特综合征的诊疗过程与药学监护重点,为药师参与临床合理用药提供参考依据。方法分析1例吉伯特综合征病人的诊疗过程及药学监护过程,指出吉伯特综合征的诊疗标准以及尿苷二磷酸葡萄糖醛酸转移酶(UGT)1A1基因多态性对药物的代谢的影响,讨论临床药师在该诊疗过程中的价值。结果吉伯特综合征发病机制与UGT1A1基因突变相关,检测UGT1A1突变基因是吉伯特综合征诊断的金标准,药师应以基因检测方法为依托,参与到病人的诊断、治疗以及出院随访的全过程,体现药师在促进合理用药,避免药物的滥用方面的价值。结论药师在帮助吉伯特综合征病人确诊及对病人进行药学监护的过程中,促进了合理用药。Objective Analyzing the diagnosis and treatment of Gilbert syndrome and the key points of pharmaceutical care so as to provide references for pharmacists to participate in rational drug use in clinical practice.Methods This study analyzed the diagnosis,treatment and pharmaceutical care of a patient with Gilbert’s syndrome,and pointed out the diagnosis and treatment standards of Gilbert syndrome and the influence of uridine diphosphate glucurono syltransferase(UGT)1 A1 gene polymorphism on the metabolism of related drugs,and discussed the value of clinical pharmacists in the diagnosis and treatment process.Results The pathogenesis of Gilbert syndrome is related to mutation of UGT1 A1 gene.The detection of UGT1 A1 mutation genes is the gold standard for the diagnosis of Gilbert syndrome.The clinical pharmacist should participate in the whole process of diagnosis,treatment,and discharge follow-up of this patient,based on genetic testing methods.This case reflected the value of clinical pharmacists in promoting rational drug use,and avoiding drug abuse.Conclusion The clinical pharmacists have promoted rational use of drugs in helping patients with Gilbert’s syndrome to be diagnosed and monitored pharmacologically.

关 键 词：药学服务 吉尔伯特病 葡糖醛酸基转移酶 基因突变 

分 类 号：R575[医药卫生—消化系统]