肿瘤治疗电场及其在胶质瘤治疗中的研究进展  

Research progress of tumor treating fields and its application in glioma

作　　者：肖友朝 任星光(综述) 段虎斌(审校)[1] XIAO You-chao;REN Xing-guang;DUAN Hu-bin(Department of Neurosurgery,the First Clinical Medical College of Shaanxi Medical University,Taiyuan 030000,Shaanxi,CHINA)

机构地区：[1]山西医科大学第一附属医院神经外科,山西太原030000

出　　处：《海南医学》2020年第24期3228-3232,共5页Hainan Medical Journal

基　　金：国家自然科学基金青年基金(编号:30600637);山西省回国留学人员重点资助(编号:2016-重点4);中国博士后科学基金(编号:2019T120195)。

摘　　要：胶质瘤是神经系统最为常见的肿瘤,目前主要治疗方案为手术切除后联合放化疗,即使经标准方案治疗的胶质瘤患者的临床预后结局依旧不理想。因此越来越多的学者不断研究胶质瘤的发病机制,探索安全有效的治疗手段,明确影响患者临床结局的相关因素,以期提高胶质瘤的临床诊治水平。相关研究表明肿瘤治疗电场(TTF)可作为治疗胶质瘤的有效措施,最新的中国脑胶质瘤诊疗规范也将其推荐为胶质瘤可行性的治疗方式。因此本文就胶质瘤的治疗现状、TTF的治疗机制、TTF治疗胶质瘤的研究进展、TTF临床应用上尚存在的局限等方面进行文献学习,并对TTF的临床应用进行展望。Glioma is the most common tumor of the nervous system.At present,the main treatment regimen is surgical resection followed by radiotherapy and chemotherapy,and the clinical outcome of glioma patients treated with standard regimen is still not ideal.Therefore,more and more scholars are constantly studying the pathogenesis of glioma,exploring safe and effective treatment methods,and clarifying the relevant factors affecting the clinical outcome of patients,so as to improve the level of clinical diagnosis and treatment of glioma.Relevant studies have shown that tumor treating fields(TTF)can be an effective measure for the treatment of glioma,and the latest Chinese guidelines for the diagnosis and treatment of brain glioma also recommend TTF as a feasible treatment for glioma.Therefore,this paper studies the current status of the treatment of glioma,the therapeutic mechanism of TTF,the research progress of TTF in the treatment of glioma,the existing limitations in the clinical application of TTF and other aspects,and looks into the prospect of the clinical application of TTF.

关 键 词：胶质瘤 肿瘤治疗电场 有丝分裂 非均匀电场 总体生存期 无进展生存期 

分 类 号：R730.5[医药卫生—肿瘤]