生姜对新型冠状病毒肺炎的防治作用探讨  

Studies on the Control Effect of Ginger on Novel Coronavirus Pneumonia

作　　者：张莉华 陈少军[2] Zhang Lihua;Chen Shaojun(Faulty of Food Science,Zhejiang Pharmaceutical College,Ningbo 315000,Zhejiang;Department of Traditional Chinese Medicine,Zhejiang Pharmaceutical College,Ningbo 315000,Zhejiang)

机构地区：[1]浙江医药高等专科学校食品学院,浙江宁波315000 [2]浙江医药高等专科学校中药学院,浙江宁波315000

出　　处：《中国食品学报》2020年第12期302-310,共9页Journal of Chinese Institute Of Food Science and Technology

基　　金：浙江省自然科学基金项目(LY18H280010);浙江省卫生科技项目(2019KY636);宁波市公益科技项目(2019C50061)。

摘　　要：采用药物生物信息学方法探讨生姜防治2019年新型冠状病毒疾病(COVID-19)的作用机制。以生姜3种活性成分(6-姜辣素、8-姜酚和10-姜酚)为研究对象,采用化学相似性搜索方法预测潜在作用靶蛋白,同时采用人工数据挖掘病毒性肺炎疾病相关蛋白,并用String 11.0构建蛋白相互作用网络。由交集获得生姜活性治疗病毒性肺炎疾病的核心靶蛋白,通过Omicshare和DAVID数据库分别对核心靶蛋白的基因本体富集和KEGG通路分析,采用Cytoscape构建生姜“活性成分-靶点-通路”网络图。结果显示,生姜活性成分涉及168个靶点,病毒性肺炎疾病相关蛋白有253个。由交集获得的18个核心靶蛋白与生姜防治病毒性肺炎相关。GO富集分析表明核心蛋白作用与炎症反应和免疫调节、细胞因子介导受体等有关。核心靶蛋白参与的KEGG通路有21条,涉及病毒感染、趋化因子通路和众多癌症通路等。研究结果表明生姜活性成分是通过多靶点和多通路对机体起整体调控作用。本研究为生姜防控COVID-19提供理论依据,也为饮食调理提供参考。To explore the action mechanisms of ginger for the treatment of COVID-19 using bioinformatics tools.Taking the three active ingredients of ginger(6-gingerol,8-gingerol and 10-gingerol)as research objects,their potential target protein targets were predicted by chemical similarity measures.Meanwhile,viral pneumonia disease-related proteins were collected by manual data mining and constructed an interaction network via String 11.0.The core targets of ginger for the treatment of viral pneumonia were intersected and analyzed.The gene ontology(GO)enrichments and the KEGG pathway enrichments were performed via Omicshare and DAVID databases,respectively.Finally,the action mechanisms network of ginger was constructed using Cytoscape 3.3.The results showed that the three active compounds of ginger could act on 168 protein targets.And there had 253 viral pneumonia disease-related proteins.Then,the intersected 18 target proteins of ginger for viral pneumonia were obtained.The gene ontology(GO)of these core proteins involved inflammatory response,immune regulation,cytokine-mediated receptors and so on.And they participated 21 KEGG pathways,including virus infection,chemokine pathway and many cancer pathways.All results showed that the active compounds of ginger played pharmacological roles through multiple targets and multiple pathways.These findings provide an overview of the action mechanisms of ginger for COVID-19 treatment,and also basis of diet therapy.

关 键 词：新型冠状病毒 2019年新型冠状病毒疾病 生姜 病毒性肺炎 

分 类 号：TS201.4[轻工技术与工程—食品科学]