GNβ3 C825T和NET T182基因多态性与儿童注意缺陷多动障碍相关性研究  

Correlation between GNβ3 C825T and NET T182 gene polymorphisms and attention deficit hyperactivity disorder in children

作　　者：梅萍 张秋莹 MEI Ping;ZHANG Qiuying(Suizhou Hospital,Hubei University of Medicine,Suizhou 441300,China)

机构地区：[1]湖北医药学院附属随州医院,湖北随州441300

出　　处：《精神医学杂志》2020年第5期367-371,共5页Journal of Psychiatry

摘　　要：目的探讨G蛋白β3亚单位(GNβ3)C825T和去甲肾上腺素转运体(NET)T182基因多态性与注意缺陷多动障碍(ADHD)儿童心理、行为问题发生与否的相关性。方法采用Achenbach儿童行为量表(CBCL)对286例6~12岁的ADHD患儿进行问卷调查,采用聚合酶链反应(PCR)对GNβ3 C825T和NET T182进行基因分型,分别对两种基因多态性与ADHD儿童行为问题的相关性进行分析。结果GNβ3 C825T基因CT/CC基因型CBCL焦虑抑郁、多动指数评分均高于TT基因型(P<0.05)。NET T182基因CT/CC基因型CBCL焦虑抑郁、社会化问题评分均高于TT基因型(P<0.05)。GNβ3 C825T和NET T182基因多态性是焦虑抑郁的影响因素(P<0.05),GNβ3 C825T基因多态性、性别是多动指数的影响因素(P<0.05),NET T182基因多态性是社会化问题的影响因素(P<0.05)。结论GNβ3 C825T和NET T182基因可能是影响ADHD儿童行为问题的重要基因,GNβ3 C825T和NET T182与焦虑抑郁问题发生有一定关联,且GNβ3 C825T和NET T182分别与多动行为和社会化问题也存在一定关联。Objective To explore the correlation between polymorphisms of G protein 3 subunit(GNβ3)C825T and norepinephrine transporter(NET)T182 gene and the occurrence of mental and behavioral problems in children with attention deficit hyperactivity disorder(ADHD).Methods A total of 286 children with ADHD aged 6~12 years old were selected and assessed with Achenbach Child Behavior Checklist(CBCL).GNβ3 C825T and NET T182 were genotyped by PCR.The correlations between the two gene polymorphisms and behavioral problems in children with ADHD were analyzed.Results The factor scores of anxiety and depression,hyperactivity index of CBCL in children with CT/CC genotypes of GNβ3 C825T were significantly higher than those in children with TT genotype of GNβ3 C825T(P<0.05).The factor scores of anxiety and depression,socialization problems of CBCL in children with CT/CC genotypes of NET T182 were significantly higher than those in children with TT genotype of NET T182(P<0.05).GNβ3 C825T and NET T182 gene polymorphisms were influencing factors for anxiety and depression(P<0.05);GNβ3 C825T gene polymorphism and gender were influencing factors for hyperactivity index(P<0.05),and NET T182 gene polymorphism was the influencing factor for socialization problems(P<0.05).Conclusion GNβ3 C825T and NET T182 may be important genes affecting the behavioral problems of ADHD children.GNβ3 C825T and NET T182 are associated with anxiety and depression,and they are also associated with hyperactivity and socialization problems,respectively.

关 键 词：GNβ3 C825T NET T182 注意缺陷多动障碍 行为问题 

分 类 号：R749.94[医药卫生—神经病学与精神病学]