Oligodendrocyte precursor cell maturation: role of adenosine receptors  

作　　者：Federica Cherchi Anna Maria Pugliese Elisabetta Coppi 

机构地区：[1]Department of Neuroscience,Psychology,Drug Research and Child Health-Neurofarba-Division of Pharmacology and Toxicology,University of Florence,Florence,Italy

出　　处：《Neural Regeneration Research》2021年第9期1686-1692,共7页中国神经再生研究（英文版）

基　　金：supported by the University of Florence(Fondi Ateneo,AMP),PRIN 2015E8EMCM_002(AMP);Fondazione Italiana Sclerosi Multipla(FISM)2019/R-Single/036(AMP and EC);supported by Fondazione Umberto Veronesi。

摘　　要：Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain and their degeneration leads to demyelinating diseases such as multiple sclerosis. Remyelination requires the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes but, in chronic neurodegenerative disorders, remyelination fails due to adverse environment. Therefore, a strategy to prompt oligodendrocyte progenitor cell differentiation towards myelinating oligodendrocytes is required. The neuromodulator adenosine, and its receptors(A1, A(2A), A(2B) and A3 receptors: A1R, A(2A)R, A(2B)R and A3R), are crucial mediators in remyelination processes. It is known that A1Rs facilitate oligodendrocyte progenitor cell maturation and migration whereas the A3Rs initiates apoptosis in oligodendrocyte progenitor cells. Our group of research contributed to the field by demonstrating that A(2A)R and A(2B)R inhibit oligodendrocyte progenitor cell maturation by reducing voltage-dependent K^+ currents necessary for cell differentiation. The present review summarizes the possible role of adenosine receptor ligands as potential therapeutic targets in demyelinating pathologies such as multiple sclerosis.

关 键 词：adenosine receptors K^+channels oligodendrocyte differentiation oligodendrocyte progenitor cells REMYELINATION 

分 类 号：R744.5[医药卫生—神经病学与精神病学]