Sericin microparticles enveloped with metal-organic networks as a pulmonary targeting delivery system for intra-tracheally treating metastatic lung cancer  

作　　者：Jia Liu Yan Deng Daan Fu Ye Yuan Qilin Li Lin Shi Guobin Wang Zheng Wang Lin Wang 

机构地区：[1]Research Center for Tissue Engineering and Regenerative Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China [2]Department of Clinical Laboratory,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China [3]Department of Gastrointestinal Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China

出　　处：《Bioactive Materials》2021年第1期273-284,共12页生物活性材料（英文）

基　　金：the National Natural Science Foundation of China(81773104,81773263,81873931,81974382 and 21708008);the Natural Science Foundation Program of Hubei Province(2017CFB652 and 2018CFB474);the Fundamental Research Funds for the Central Universities(2017KFYXJJ241);the Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College of HUST,and Health Commission of Hubei Province scientific research project(WJ2019M155);the Graduates'Innovation Fund of Huazhong University of Science and Technology(2019ygscxcy069).

摘　　要：Chemotherapy is one of the major approaches for the treatment of metastatic lung cancer.However,systemic chemotherapy is limited by poor therapeutic efficiency and severe toxic side effects,due to the extremely low delivery efficacy and non-specificity of anticancer drugs.Herein,we report a sericin microparticles enveloped with metal-organic networks as a pulmonary delivery system for treating lung metastasis of breast cancer in an animal model.The sericin microparticles(SMPs)were prepared using water in oil(w/o)emulsification method.After doxorubicin(DOX)loading,tannic acid(TA)/ferric irons(Fe3+)based metal organic networks(MON)were coated on the particles to obtain DOX-loaded microparticles(DOX@SMPs-MON).The SMPs-MON with good biocompatibility could effectively encapsulate DOX and sustainably unload cargos in a pH-dependent manner.The DOX-loaded microparticles could be uptaken by 4T1 cells,and effectively kill the cancer cells.In vivo,DOX@SMPs-MON was deposited in the lungs and remained for over 5 days after pulmonary administration.In contrast to conventional DOX treatment that did not show significantly inhibitory effects on lung metastatic tumor,DOX@SMPs-MON markedly decreased the number and size of metastatic nodules in lungs,and the lung weight and appearance were similar to those of healthy mice.In summary,the sericin microparticles with MON wrapping might be a promising pulmonary delivery system for treating lung metastatic cancer.

关 键 词：Sericin microparticles Pulmonary delivery system Metal organic networks DOXORUBICIN Metastatic lung cancer 

分 类 号：R734.2[医药卫生—肿瘤]