Advances and prospects in biomimetic multilayered scaffolds for articular cartilage regeneration  

作　　者：Liwei Fu Zhen Yang Cangjian Gao Hao Li Zhiguo Yuan Fuxin Wang Xiang Sui Shuyun Liu Quanyi Guo 

机构地区：[1]School of Medicine,Nankai University,No.94 Weijin Road,Nankai District,Tianjin 300071,China [2]Beijing Key Lab of Regenerative Medicine in Orthopedics,Key Laboratory of Musculoskeletal Trauma and War Injuries PLA,Institute of Orthopedics,The First Medical Center,Chinese PLA General Hospital,No.28 Fuxing Road,Haidian District,Beijing 100853,China [3]Department of Bone and Joint Surgery,Renji Hospital,School of Medicine,Shanghai Jiaotong University,No.160 Pujian Road,Pudong New District,Shanghai 200127,China

出　　处：《Regenerative Biomaterials》2020年第6期527-542,共16页再生生物材料（英文版）

基　　金：supported by the National Key Research and Development Program of China(No.2019YFA0110600);the National Natural Science Foundation of China(No.81772319).

摘　　要：Due to the sophisticated hierarchical structure and limited reparability of articular cartilage(AC),the ideal regeneration of AC defects has been a major challenge in the field of regenerative medicine.As defects progress,they often extend from the cartilage layer to the subchondral bone and ultimately lead to osteoarthritis.Tissue engineering techniques bring new hope for AC regeneration.To meet the regenerative requirements of the heterogeneous and layered structure of native AC tissue,a substantial number of multilayered biomimetic scaffolds have been studied.Ideal multilayered scaffolds should generate zone-specific functional tissue similar to native AC tissue.This review focuses on the current status of multilayered scaffolds developed for AC defect repair,including design strategies based on the degree of defect severity and the zone-specific characteristics of AC tissue,the selection and composition of biomaterials,and techniques for design and manufacturing.The challenges and future perspectives of biomimetic multilayered scaffold strategies for AC regeneration are also discussed.

关 键 词：biomimetic multilayered scaffold articular cartilage REGENERATION tissue engineering OSTEOCHONDRAL 

分 类 号：R318[医药卫生—生物医学工程]