Sequencing and analysis of John Cunningham polyomavirus DNA from acquired immunodeficiency syndrome patients with progressive multifocal leukoencephalopathy  

作　　者：Cai-Qin Hu Jun-Wei Su Meng-Yan Wang Yong-Zheng Guo Li-Jun Xu Ran Tao Yi-Rui Xie Ying Huang Biao Zhu 

机构地区：[1]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310003,China [2]Xixi Hospital of Hangzhou,Hangzhou,Zhejiang 310023,China

出　　处：《Chinese Medical Journal》2020年第23期2887-2889,共3页中华医学杂志（英文版）

基　　金：This work was supported by a grant from the National Major Science and Technology Projects for Important Infectious Diseases in China(No.2017ZX10202102-002-002)。

摘　　要：The John Cunningham(JC)polyomavirus was first discovered in a patient with progressive multifocal leukoencephalopathy(PML)in 1971.The diagnosis for PML includes definite(etiological)diagnosis and presumptive(clinical)diagnosis.The etiological diagnosis consists of cerebrospinal fluid(CSF)-confirmed PML(evidence of JC polyomavirus in the CSF)and tissue-confirmed PML(evidence of JC polyomavirus in brain tissues).The clinical diagnosis of PML is defined as evidence of typical clinical and magnetic resonance imaging(MRI)findings.[1]JC polyomavirus has a non-enveloped,closed circular double-stranded DNA genome with a full length of 5120 kb.The virus genome is composed of an early coding region,a late coding region,and a non-coding control region(NCCR).The early coding region encodes five proteins:the large tumor(T)antigen,the small T antigen,and three other T antigen-splicing variants(T’135,T’136,and T’165).

关 键 词：DIAGNOSIS CLINICAL ENCEPHALOPATHY 

分 类 号：R512.91[医药卫生—内科学] R742[医药卫生—临床医学]