山东省市售蜂蜜中氯霉素和甲硝唑监测及风险评估分析  

Monitoring and risk assessment analysis of chloramphenicol and metronidazole in honey,Shandong Province

作　　者：邢燕[1,2] 王敏 高慧[1,2] 张晶皎 袁月[1,2] 刘婷婷 王勤 XING Yan;WANG Ming;GAO Hui;ZHANG Jing-jiao;YUAN Yue;LIU Ting-ting;WANG Qin(Zibo Center for Disease Control and Prevention,Zibo,Shandong 255026,China)

机构地区：[1]淄博市疾病预防控制中心,山东255026 [2]淄博市环境有机污染与人群健康监测分析重点实验室 [3]济宁学院生命科学与工程系

出　　处：《现代预防医学》2021年第1期174-177,共4页Modern Preventive Medicine

基　　金：淄博市科技发展计划项目(2017kj010071);山东省医药卫生科技发展计划项目(2017WS378)。

摘　　要：目的对山东省市采集蜂蜜进行监测,了解蜂蜜中氯霉素和甲硝唑兽药残留情况。方法采用MCS固相萃取柱进行样品净化,液相色谱串联质谱同时测定蜂蜜中的甲硝唑(MTZ)和氯霉素(CAP)含量,内标法定量。结果 170份样品中,CAP检出率为15.3%,检出范围为N.D.~3.302μg/kg;而MTZ检出率为1.2%,检出范围为N.D.~60.20μg/kg。散装蜂蜜样品的检出率明显高于定型包装样品;枣花蜜的氯霉素检出率最高。结论山东省市售蜂蜜中存在氯霉素和甲硝唑残留情况,政府和市场监管部门需要增加重视,杜绝抗生素的滥用。Objective To investigate the residue of veterinary drugs,such as chloramphenicol and metronidazole,in honey which were collected in Shandong province.Methods The samples were purified by MCS solid phase extraction column,and the contents of MTZ and CAP in honey were determined by liquid chromatography tandem mass spectrometry.Results Among 170 samples,the CAP detection rate was 15.3%and the detection range was N.D.~3.302μg/kg.The detection rate of MTZ was 1.2%,and the detection range was N.D.~60.20μg/kg.The detection rate of bulk honey samples was significantly higher than that of stereotypical package samples.The detection rate of chloramphenicol in jujube nectar was the highest.Conclusion Chloramphenicol and metronidazole residues are found in honey in Shandong province,and the government and market regulators need to pay more attention to stop the abuse of antibiotics.

关 键 词：蜂蜜 氯霉素 甲硝唑 监测 

分 类 号：R155.5[医药卫生—营养与食品卫生学]