Relationship between serum Dickkopf-1 and albuminuria in patients with type 2 diabetes  

作　　者：Ning-Ning Hou Cheng-Xia Kan Na Huang Yong-Ping Liu En-Wen Mao Yu-Ting Ma Fang Han Hong-XiSun Xiao-Dong Sun 

机构地区：[1]Department of Endocrinology,Affiliated Hospital of Weifang Medical University,Weifang 261031,Shandong Province,China [2]Department of Pathology,Affiliated Hospital of Weifang Medical University,Weifang 261031,Shandong Province,China

出　　处：《World Journal of Diabetes》2021年第1期47-55,共9页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by National Natural Science Foundation of China,No.81870593;Natural Science Foundation of Shandong Province of China,No.ZR2018MH008;Shandong Province Higher Educational Science and Technology Program for Youth Innovation,No.2020KJL004;Municipal Science and Technology Development Program of Weifang,No.2018YX025.

摘　　要：BACKGROUND Diabetic kidney disease is a microvascular complication of diabetes with complex pathogenesis.Wingless signaling-mediated renal fibrosis is associated with diabetic kidney disease.Dickkopf-1,a negative regulator of Wingless,has been proven to participate in renal fibrosis,glucose metabolism,and inflammation.However,whether serum Dickkopf-1 levels are associated with diabetic kidney disease remains unclear.AIM To assess the relationship between serum Dickkopf-1 levels and albuminuria in individuals with type 2 diabetes.METHODS Seventy-three type 2 diabetes patients and 24 healthy individuals were enrolled in this case-control study.Diabetic individuals were separated into normal albuminuria,microalbuminuria,and macroalbuminuria groups based on their urinary albumin/creatinine ratios(UACRs).Clinical characteristics and metabolic indices were recorded.Serum Dickkopf-1 levels were determined by enzymelinked immunosorbent assay.RESULTS No significant difference in serum Dickkopf-1 levels was found between healthy individuals and the normal albuminuria group.However,the levels in the microalbuminuria group were significantly lower than those in the normal albuminuria group(P=0.017),and those in the macroalbuminuria group were the lowest.Bivariate analysis revealed that serum Dickkopf-1 levels were positively correlated with hemoglobin A1c level(r=0.368,P<0.01)and estimated glomerular filtration rate(r=0.339,P<0.01),but negatively correlated with diabetes duration(r=-0.231,P=0.050),systolic blood pressure(r=-0.369,P=0.001),serum creatinine level(r=-0.325,P<0.01),and UACR(r=-0.459,P<0.01).Multiple and logistic regression showed that serum Dickkopf-1 levels were independently associated with UACR(odds ratio=0.627,P=0.021).CONCLUSION Serum Dickkopf-1 levels are negatively associated with UACR.Lower serum Dickkopf-1 levels could be a critical risk factor for albuminuria in diabetes.

关 键 词：DICKKOPF-1 ALBUMINURIA Diabetic kidney disease Type 2 diabetic mellitus WINGLESS MICROALBUMINURIA 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]