Repeatedly elevatedγ-glutamyltransferase levels are associated with an increased incidence of digestive cancers:A population-based cohort study  

作　　者：Chang-Hoon Lee Kyungdo Han Da Hye Kim Min-Sun Kwak 

机构地区：[1]Department of Internal Medicine,Seoul National University Hospital,Seoul 03080,South Korea [2]Department of Statistics and Actuarial Science,Soongsil University,Seoul 06978,South Korea [3]Department of Biostatistics,College of Medicine,Catholic University of Korea,Seoul 06591,South Korea [4]Department of Internal Medicine,Healthcare Research Institute,Healthcare System Gangnam Center,Seoul National University Hospital,Seoul 06236,South Korea

出　　处：《World Journal of Gastroenterology》2021年第2期176-188,共13页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND The association between elevatedγ-glutamyltransferase(GGT)at a certain point and incident cancer has been suggested;however,no study has evaluated the association between repeatedly elevated GGT and cancer incidence.AIM To investigate the effects of repeatedly elevated GGT on the incidence of digestive cancers.METHODS Participants who had undergone health screening from 2009 to 2012 and 4 consecutive previous examinations were enrolled.GGT points were calculated as the number of times participants met the criteria of quartile 4 of GGT in four serial measurements(0-4 points).Multivariable Cox proportional hazard regression models were applied.RESULTS In total,3559109 participants were included;among them,43574 digestive cancers developed during a median of 6.8 years of follow-up.The incidence of total digestive cancers increased in a dose-response manner in men[adjusted hazard ratio(aHR)compared with those with 0 GGT points=1.28 and 95%confidence interval(CI)=1.24-1.33 in those with 1 point;aHR=1.40 and 95%CI=1.35-1.46 in those with 2 points;aHR=1.52 and 95%CI=1.46-1.58 in those with 3 points;aHR=1.88 and 95%CI=1.83-1.94 in those with 4 points;P for trend<0.001].This trend was more prominent in men than in women and those with healthy habits(no smoking,no alcohol consumption,and a low body mass index)than in those with unhealthy habits.CONCLUSION Repeatedly elevated GGT levels were associated with an increased risk of incident digestive cancer in a dose-responsive manner,particularly in men and those with healthy habits.Repeated GGT measurements may be a good biomarker of incident digestive cancer and could help physicians identify high-risk populations.

关 键 词：GAMMA-GLUTAMYLTRANSFERASE CANCER Digestive organ Serial exam Incident cancer Biomarker 

分 类 号：R735[医药卫生—肿瘤]