Harnessing sub-organelle metabolism for biosynthesis of isoprenoids in yeast  

作　　者：Xuan Cao Shan Yang Chunyang Cao Yongjin J.Zhou 

机构地区：[1]Division of Biotechnology,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,457 Zhongshan Road,Dalian,116023,PR China [2]CAS Key Laboratory of Separation Science for Analytical Chemistry,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian,116023,PR China [3]Dalian Key Laboratory of Energy Biotechnology,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian,116023,PR China [4]University of Chinese Academy of Sciences,Beijing,100049,PR China [5]School of Food Science and Technology,Dalian Polytechnic University,Dalian,116034,PR China

出　　处：《Synthetic and Systems Biotechnology》2020年第3期179-186,共8页合成和系统生物技术（英文）

基　　金：This study was financially supported by National Natural Science Foundation of China(Grant no.21877111 and no.21922812);China Postdoctoral Science Foundation(199936).

摘　　要：Current yeast metabolic engineering in isoprenoids production mainly focuses on rewiring of cytosolic metabolic pathway.However,the precursors,cofactors and the enzymes are distributed in various sub-cellular compartments,which may hamper isoprenoid biosynthesis.On the other side,pathway compartmentalization provides several advantages for improving metabolic flux toward target products.We here summarize the recent advances on harnessing sub-organelle for isoprenoids biosynthesis in yeast,and analyze the knowledge about the localization of enzymes,cofactors and metabolites for guiding the rewiring of the sub-organelle metabolism.This review may provide some insights for constructing efficient yeast cell factories for production of isoprenoids and even other natural products.

关 键 词：ISOPRENOIDS YEAST COMPARTMENTALIZATION Sub-organelle metabolism 

分 类 号：Q81[生物学—生物工程]