ISOPRENOIDS

作品数：21被引量：127H指数：7
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Manipulation of IME4 expression, a global regulation strategy for metabolic engineering in Saccharomyces cerevisiae被引量：1
《Acta Pharmaceutica Sinica B》2023年第6期2795-2806,共12页Jianxun Zhu Tianyue An Wenlong Zha Ke Gao Ting Li Jiachen Zi 
supported by the National Key Research and Development Program of China [2022YFF1100304 (2022YFF1100300), China];National Natural Science Foundation of China [82293682 (82293680), China];Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2021-RC350-009, China);the CAMS Innovation Fund for Medical Sciences (2021-I2M-1-029, China)。
Metabolic engineering has been widely used for production of natural medicinal molecules.However, engineering high-yield platforms is hindered in large part by limited knowledge of complex regulatory machinery of meta...
关键词：RNA m^(6)A modification Metabolic engineering Saccharomyces cerevisiae ISOPRENOIDS Aromatic compounds 
MEP pathway products allosterically promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedback-regulate their supply
《Plant Communications》2023年第3期171-182,共12页supply Xueni Di David Ortega-Alarcon Ramu Kakumanu Javier Iglesias-Fernandez Lucia Diaz Edward E.K.Baidoo Adrian Velazquez-Campoy Manuel Rodríguez-Concepción Jordi Perez-Gil 
funded by grants from the Spanish MCIN/AEI/10.13039/501100011033;European ERDF/FEDER,NextGeneration EU/PRTR and PRIMA programs(PID2020-115810GB-I00;UToPIQ-PCI2021-121941 to M.R.-C.and BFU2016-78232-P to A.V.-C.).M.R.-C.is also supported by CSIC(202040E299);Generalitat Valenciana(PROMETEU/2021/056).R.K.and E.E.K.B.conducted the metabolite analysis at the Joint BioEnergy Institute(http://www.jbei.org),supported by the US Department of Energy,Office of Science,Office of Biological and Environmental Research under contract DE-AC02-05CH11231 between Lawrence Berkeley National Laboratory and the US Department of Energy.J.P.-G;was supported by a Marie Curie International Outgoing Fellowship within the EC-FP7 Program(project 627639);X.D.was supported by the China Scholarship Council and D.O.-A.by an MCIN/AEI/fellowship(BES-2017-080739).
Isoprenoids are a very large and diverse family of metabolites required by all living organisms.All isoprenoids derive fromthe double-bond isomers isopentenyl diphosphate(IPP)and dimethylallyl diphosphate(DMAPP),which...
关键词：ISOPRENOIDS DXS feedback regulation ALLOSTERIC monomerization 
Open avenues for carotenoid biofortification of plant tissues
《Plant Communications》2023年第1期228-237,共10页Luca Morelli Manuel Rodriguez-Concepcion 
supported by grants from the Spanish MCIN/AEI/10.13039/501100011033;European NextGeneration EU/PRTR and PRIMA programs to M.R.-C.(PID2020-115810GB-I00 and UToPIQ-PCI2021-121941);supported by CSIC(202040E299);Generalitat Valenciana(PROMETEU/2021/056);funded by a PhD fellowship from“la Caixa”Foundation(INPhINIT program LCF/BQ/IN18/11660004);an EMBO short-term fellowship(ASTF 8907)for a short stay at the University of Neuchatel(Switzerland).
Plant carotenoids are plastidial isoprenoids that function as photoprotectants,pigments,and precursors of apocarotenoids such as the hormones abscisic acid and strigolactones.Humans do not produce carotenoids but need...
关键词：BIOFORTIFICATION BIOTECHNOLOGY carotenoids plastidial isoprenoids vitamin A 
Engineering for life in toxicity:Key to industrializing microbial synthesis of high energy density fuels
《Engineering Microbiology》2022年第2期10-20,共11页Lijuan Liu Wenzhi Bao Xiao Men Haibo Zhang 
supported by National Natural Science Foundation of China(No.32170084);Shandong Provincial Science Fund for Distin-guished Young Scholars(No.ZR2020JQ11),Young Taishan Scholars(No.TSQN201909159);Research and innovation fund of Shandong En-ergy Institute(No.SEI I202135 and No.SEI I202113);Natural Science Foundation of Shandong Province(No.ZR2019BC060)and Youth Inno-vation Promotion Association,CAS(Y2021063).
With the growing demand for air transportation combined with global concerns about environmental issues and the instability and lack of renewability of the oil market,microbial production of high energy density fuels ...
关键词：Toxicity engineering Bio-jet fuels Isoprenoids and aromatic hydrocarbons 
Harnessing sub-organelle metabolism for biosynthesis of isoprenoids in yeast被引量：8
《Synthetic and Systems Biotechnology》2020年第3期179-186,共8页Xuan Cao Shan Yang Chunyang Cao Yongjin J.Zhou 
This study was financially supported by National Natural Science Foundation of China(Grant no.21877111 and no.21922812);China Postdoctoral Science Foundation(199936).
Current yeast metabolic engineering in isoprenoids production mainly focuses on rewiring of cytosolic metabolic pathway.However,the precursors,cofactors and the enzymes are distributed in various sub-cellular compartm...
关键词：ISOPRENOIDS YEAST COMPARTMENTALIZATION Sub-organelle metabolism 
Rapid Quantitative Determination of Isoprene Monomer in Living Taraxacum kok-saghyz by Ultra-High Performance Liquid Chromatography Tandem Mass Spectrometry被引量：1
《China Petroleum Processing & Petrochemical Technology》2020年第2期30-36,共7页Xiang Tong Guo Tianyang Zhang Xi Chen Yunhan Dong Yiyang Zhang Jichuan Ma Qiang Zhang Liqun 
the supports of the National Key Research and Development of BioBased Rubber(2017YFB0306900&2017YFB0306901);the National Natural Science Foundation of China(51673012);the Fundamental Research Funds for the Central Universities(PYBZ1828);the Beijing Technology and Business Universtiy Youth Scholoars Funds(PXM2019014213000007)。
Taraxacum kok-saghyz(TKS)is rich in natural rubber(NR),a natural organic macromolecular compound composed of cis-1,4-polyisoprene,and may become the second NR-bearing plant for biochemical engineering development.In t...
关键词：QUANTITATION Taraxacum kok-saghyz(TKS) ISOPRENOIDS ultra-high performance liquid chromatography tandem mass spectrometry(UHPLC-MS/MS) natural rubber(NR) 
An Improved Method for Fractionation of Small Quantities of Lettuce Latex
《American Journal of Plant Sciences》2018年第10期2004-2007,共4页Thomas A. McKeon Jenny Brichta 
While large quantities of latex can be handled either by standard extraction techniques such as Soxhlet extraction or accelerated solvent extraction (ASE), smaller samples on the order of 0.3 - 0.5 g require handling ...
关键词：Resin Rubber ISOPRENOIDS LACTUCA SATIVA L. Solvent Extraction 
Engineering metabolic pathways in Amycolatopsis japonicum for the optimization of the precursor supply for heterologous brasilicardin congeners production被引量：4
《Synthetic and Systems Biotechnology》2018年第1期56-63,共8页Paul N.Schwarz Luisa Roller Andreas Kulik Wolfgang Wohlleben Evi Stegmann 
This work was funded by Bundesministerium für Bildung und Forschung(BMBF)(FKZ 031A568B),in the frame of the ERA-NET-IB project“NeBrasCa”.
The isoprenoid brasilicardin A is a promising immunosuppressant compound with a unique mode of action,high potency and reduced toxicity compared to today's standard drugs.However,production of brasilicardin has been h...
关键词：Norcardia terpenica IFM0406 Mevalonate pathway ISOPRENOIDS PRENYLTRANSFERASES 
Engineering of Yarrowia lipolytica for production of astaxanthin被引量：22
《Synthetic and Systems Biotechnology》2017年第4期287-294,共8页Kanchana Rueksomtawin Kildegaard Belen Adiego-Perez David Domenech Belda Jaspreet Kaur Khangura Carina Holkenbrink Irina Borodina 
This research was financially supported by the Novo Nordisk Foundation(grant number NNF15OC0016592);BAD was supported by the ERASMUS Traineeship program.We acknowledge Mette Kristensen for technical assistance on HPLC analysis.
Astaxanthin is a red-colored carotenoid,used as food and feed additive.Astaxanthin is mainly produced by chemical synthesis,however,the process is expensive and synthetic astaxanthin is not approved for human consumpt...
关键词：ASTAXANTHIN Β-CAROTENE ISOPRENOIDS Oleaginous yeast Yarrowia lipolytica Metabolic engineering 
Metabolic engineering for the microbial production of isoprenoids:Carotenoids and isoprenoid-based biofuels被引量：8
《Synthetic and Systems Biotechnology》2017年第3期167-175,共9页Fu-Xing Niu Qian Lu Yi-Fan Bu Jian-Zhong Liu 
the National Natural Science Foundation of China(Grant NO.21276289);the Natural Science Foundation of Guangdong Province(NO.2015A030311036);the Project of the Scientific and Technical Program of Guangdong Province(NO.2015A010107004);the Project of the Scientific and Technical Program of Guangzhou(NO.201607010028)for their financial support.
Isoprenoids are the most abundant and highly diverse group of natural products.Many isoprenoids have been used for pharmaceuticals,nutraceuticals,flavors,cosmetics,food additives and biofuels.Carotenoids and isoprenoi...
关键词：Carotenoids Isoprenoid-based biofuel Metabolic engineering Synthetic biology 
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