PRENYLTRANSFERASES

作品数：3被引量：4H指数：1
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De novo biosynthesis of 8‑prenylnaringenin in Saccharomyces cerevisiae improved by screening and engineering of prenyltransferases and precursor pathway
《Systems Microbiology and Biomanufacturing》2023年第4期647-658,共12页Chaojie Guo Yongkun Lv Hongbiao Li Jingwen Zhou Sha Xu 
supported by the National Key Research and Development Program of China(2019YFA0904800);the National Science Fund for Excellent Young Scholars(21822806);the National Natural Science Foundation of China(21908078).
8-Prenylnaringenin(8-PN)is a valuable medical phytoestrogen,which is a precursor to many prenylated flavonoids.How-ever,the availability of 8-PN is limited by inefficient prenyltransferases(PTs)and inadequate substrat...
关键词：Saccharomyces cerevisiae PRENYLTRANSFERASES Prenylated flavonoid Protein engineering 8-Prenylnaringenin 
Microbial soluble aromatic prenyltransferases for engineered biosynthesis
《Synthetic and Systems Biotechnology》2021年第2期51-62,共12页He-Ping Chen Ikuro Abe 
supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education,Culture,Sports,Science and Technology,Japan(JSPS KAKENHI Grant No.JP16H06443 and JP20H00490);Japan Science and Technology Agency(JST SICORP Grant No.JPMJSC1701);H.P.C.is a recipient of the JSPS Postdoctoral Fellowship for Foreign Researchers(ID No.P19413).
Prenyltransferase(PTase)enzymes play crucial roles in natural product biosynthesis by transferring isoprene unit(s)to target substrates,thereby generating prenylated compounds.The prenylation step leads to a diverse g...
关键词：Microbial prenyltransferase BIOSYNTHESIS Enzyme engineering PRENYLATION Synthetic biology 
Engineering metabolic pathways in Amycolatopsis japonicum for the optimization of the precursor supply for heterologous brasilicardin congeners production被引量：4
《Synthetic and Systems Biotechnology》2018年第1期56-63,共8页Paul N.Schwarz Luisa Roller Andreas Kulik Wolfgang Wohlleben Evi Stegmann 
This work was funded by Bundesministerium für Bildung und Forschung(BMBF)(FKZ 031A568B),in the frame of the ERA-NET-IB project“NeBrasCa”.
The isoprenoid brasilicardin A is a promising immunosuppressant compound with a unique mode of action,high potency and reduced toxicity compared to today's standard drugs.However,production of brasilicardin has been h...
关键词：Norcardia terpenica IFM0406 Mevalonate pathway ISOPRENOIDS PRENYLTRANSFERASES 
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