Drug-loaded chitosan film prepared via facile solution casting and air-drying of plain water-based chitosan solution for ocular drug delivery  

作　　者：Boxuan Li Juan Wang Qin Gui Hu Yang 

机构地区：[1]Tianjin Key Laboratory of Biomedical Materials,Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy,Institute of Biomedical Engineering,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin,300192,China [2]Department of Chemical and Life Science Engineering,Virginia Commonwealth University,Richmond,VA,23219,United States [3]College of Materials Science and Engineering,Sichuan University,Chengdu,Sichuan,610065,China [4]Department of Pharmaceutics,Virginia Commonwealth University,Richmond,VA,23298,United States [5]Massey Cancer Center,Virginia Commonwealth University,Richmond,VA,23298,United States

出　　处：《Bioactive Materials》2020年第3期577-583,共7页生物活性材料（英文）

基　　金：supported,in part,by the National Institutes of Health(R01EY024072)(HY);the Fundamental Research Funds for the Central Universities(Grant No.3332019100,2019PT320028)(BL).

摘　　要：Chitosan is a nature-based polymer with low toxicity,excellent biocompatibility and biodegradability.However,the intractable solubility of chitosan in water and most conventional solvents hampers its biomedical applications.Following the dissolution method for dissolving chitosan in plain water developed by us,chitosan was dissolved in ionic liquid followed by overnight freezing at−20℃ and subsequent solvent exchange with plain water at room temperature.In this study,we fabricated a drug-carrying chitosan film via solution casting and air-drying by using the plain water-based chitosan solution.Specifically,brimonidine tartrate(BT),an antiglaucoma drug,was dissolved in the plain-water based solution and used to prepare BT-loaded chitosan film,i.e.,chitosan-BT film.The resulting film is transparent,structurally stable,and mucoadhesive.Micro-sized antiglaucoma BT drug crystals form and are well dispersed in the chitosan film.The chitosan-BT film enables BT to have a high corneal permeability with fast drug release kinetics for potential ocular drug delivery.

关 键 词：CHITOSAN Plain water BRIMONIDINE GLAUCOMA Ionic liquid 

分 类 号：R318[医药卫生—生物医学工程]