Reversing cold tumors to hot: An immunoadjuvant-functionalized metalorganic framework for multimodal imaging-guided synergistic photoimmunotherapy  

作　　者：Zhijin Fan Hongxing Liu Yaohua Xue Jingyan Lin Yu Fu Zhaohua Xia Dongming Pan Jian Zhang Kun Qiao Zhenzhen Zhang Yuhui Liao 

机构地区：[1]Molecular Diagnosis and Treatment Center for Infectious Diseases,Dermatology Hospital,Southern Medical University,Guangzhou,510091,China [2]Department of Urology,Guangzhou Institute of Urology,Guangdong Key Laboratory of Urology,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou Medical University,Guangzhou,Guangdong,510230,China [3]Department of Thoracic Surgery,Shenzhen Third People's Hospital,Shenzhen,518110,China [4]Department of Biomedical Engineering,School of Basic Medical Science,Guangzhou Medical University,Guangzhou,511436,China [5]Institute for Brain Research and Rehabilitation,South China Normal University,Guangzhou,510631,China

出　　处：《Bioactive Materials》2021年第2期312-325,共14页生物活性材料（英文）

基　　金：This work was supported by grants from the National Natural Science Foundation of China,China(21904145,81972019 and 31700150);China Postdoctoral Science Foundation,China(2018M633273);Chen Jingyu team of Sanming Project of Medicine in Shenzhen,China(SZSM201812058);Guangdong Provincial Science and Technology Plan project,China(No.2017B030314108).

摘　　要：Immunotherapy assays using immunoadjuvants and tumor antigens could greatly increase the survival rates of patients with malignant tumors.As effective carriers,metal-organic frameworks(MOFs)have been widely utilized in cancer therapy due to their remarkable histocompatibility and low toxicity.Herein,we constructed a multimodal imaging-guided synergistic cancer photoimmunotherapy by employing a specific MOF(MIL101-NH2)as the core carrier;the MOF was dual-dressed with photoacoustic and fluorescent signal donors(indocyanine green,ICG)and immune adjuvants(cytosine-phosphate-guanine sequence,CpG)and named [e-mail] nanocarrier could passively target the tumor site through the EPR effect and achieve multimodal imaging(fluorescence,photoacoustic,photothermal and magnetic resonance imaging)of the tumor.Synergistic cancer photoimmunotherapy was achieved via simultaneous photodynamic and photothermal methods with 808 nm laser irradiation.ICG-CpG@MOF achieved the GSH-controlled release of immunoadjuvant into the tumor microenvironment.Furthermore,the released tumor-associated antigen along with CpG could induce the transformation of tumor cells from cold to hot by activating the immune system,which significantly enhanced tumor cytotoxicity and achieved high cure rates with minimal side-effects.This strategy utilizing multimodal imaging and synergistic cancer photoimmunotherapy provides a promising approach for the diagnosis and treatment of cancer.

关 键 词：Synergistic cancer photoimmunotherapy Multimodal imaging Metal-organic frameworks CPG Hot tumor 

分 类 号：R730.5[医药卫生—肿瘤]